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首页> 美国卫生研究院文献>Scientific Reports >Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models
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Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models

机译：适用于全球健康状况的低成本光动力疗法设备：在3D肿瘤模型中表征电池供电的LED性能和智能手机成像

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摘要

A lack of access to effective cancer therapeutics in resource-limited settings is implicated in global cancer health disparities between developed and developing countries. Photodynamic therapy (PDT) is a light-based treatment modality that has exhibited safety and efficacy in the clinic using wavelengths and irradiances achievable with light-emitting diodes (LEDs) operated on battery power. Here we assess low-cost enabling technology to extend the clinical benefit of PDT to regions with little or no access to electricity or medical infrastructure. We demonstrate the efficacy of a device based on a 635 nm high-output LED powered by three AA disposable alkaline batteries, to achieve strong cytotoxic response in monolayer and 3D cultures of A431 squamous carcinoma cells following photosensitization by administering aminolevulinic acid (ALA) to induce the accumulation of protoporphyrin IX (PpIX). Here we characterize challenges of battery-operated device performance, including battery drain and voltage stability specifically over relevant PDT dose parameters. Further motivated by the well-established capacity of PDT photosensitizers to serve as tumour-selective fluorescence contrast agents, we demonstrate the capability of a consumer smartphone with low-cost add-ons to measure concentration-dependent PpIX fluorescence. This study lays the groundwork for the on-going development of image-guided ALA-PDT treatment technologies for global health applications.
机译：在资源有限的环境中缺乏有效的癌症治疗方法的途径，与发达国家和发展中国家之间的全球癌症健康差异有关。光动力疗法（PDT）是一种基于光的治疗方式，已在临床上显示出安全性和有效性，使用的波长和辐照度可以通过以电池供电的发光二极管（LED）实现。在这里，我们评估了低成本的支持技术，以将PDT的临床益处扩展到几乎没有电力或医疗基础设施的地区。我们证明了基于由三节AA一次性碱性电池供电的635 nm高输出LED的设备的功效，通过施用氨基乙酰丙酸（ALA）诱导光敏化后，在A431鳞状细胞的单层和3D培养中实现了强大的细胞毒性反应原卟啉IX（PpIX）的积累。在这里，我们描述了电池供电设备性能的挑战，包括电池消耗和电压稳定性（特别是在相关的PDT剂量参数上）。受PDT光敏剂已确立的用作肿瘤选择性荧光造影剂的能力的进一步激励，我们证明了具有低成本附加组件的家用智能手机能够测量浓度依赖性PpIX荧光的能力。这项研究为持续发展的影像指导的ALA-PDT治疗技术为全球卫生应用奠定了基础。

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