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Raman spectroscopy explores molecular structural signatures of hidden materials in depth: Universal Multiple Angle Raman Spectroscopy

机译:拉曼光谱学深入探索隐藏材料的分子结构特征:通用多角度拉曼光谱学

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摘要

Non-invasive 3D imaging in materials and medical research involves methodologies such as X-ray imaging, MRI, fluorescence and optical coherence tomography, NIR absorption imaging, etc., providing global morphological/density/absorption changes of the hidden components. However, molecular information of such buried materials has been elusive. In this article we demonstrate observation of molecular structural information of materials hidden/buried in depth using Raman scattering. Typically, Raman spectroscopic observations are made at fixed collection angles, such as, 90°, 135°, and 180°, except in spatially offset Raman scattering (SORS) (only back scattering based collection of photons) and transmission techniques. Such specific collection angles restrict the observations of Raman signals either from or near the surface of the materials. Universal Multiple Angle Raman Spectroscopy (UMARS) presented here employs the principle of (a) penetration depth of photons and then diffuse propagation through non-absorbing media by multiple scattering and (b) detection of signals from all the observable angles.
机译:材料和医学研究中的非侵入式3D成像涉及X射线成像,MRI,荧光和光学相干断层扫描,NIR吸收成像等方法,可提供隐藏组件的整体形态/密度/吸收变化。但是,这种掩埋材料的分子信息难以捉摸。在本文中,我们演示了使用拉曼散射观察到的隐藏/深埋材料的分子结构信息。通常,拉曼光谱观察是在固定的收集角度(例如90°,135°和180°)下进行的,除了空间偏移拉曼散射(SORS)(仅基于光子的反向散射收集)和透射技术。这样的特定收集角度限制了从材料表面或其附近观察拉曼信号。本文介绍的通用多角度拉曼光谱法(UMARS)采用以下原理:(a)光子的穿透深度,然后通过多次散射和通过(b)从所有可观察角度检测信号,通过非吸收性介质扩散传播。

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