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首页> 美国卫生研究院文献>Journal of Korean Medical Science >Erythropoietin does not affect nitric oxide system in rats with chronic renal failure.
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Erythropoietin does not affect nitric oxide system in rats with chronic renal failure.

机译：促红细胞生成素不会影响慢性肾功能衰竭大鼠的一氧化氮系统。

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摘要

We investigated to see whether an altered role of nitric oxide (NO) system is involved in erythropoietin (EPO)-induced hypertension in chronic renal failure (CRF). Male Sprague-Dawley rats were five-sixths nephrectomized to induce CRF. Six weeks after the operation, EPO or vehicle was injected for another 6 weeks. Plasma and urine nitriteitrate (NOx) levels were determined. Expression of NO synthase (NOS) proteins in the aortae and kidneys were also determined. In addition, the isometric tension of isolated aorta in response to acetylcholine and nitroprusside was examined. Blood pressure progressively rose in CRF groups, the degree of which was augmented by EPO treatment. Plasma NOx levels did not differ among the groups, while urine NOx levels were lower in CRF groups. Endothelial NOS expression was lower in the kidney and aorta in CRF rats, which was not further affected by EPO-treatment. The inducible NOS expression in the kidney and aorta was not different among the groups. Acetylcholine and sodium nitroprusside caused dose-dependent relaxations of aortic rings, the degree of which was not altered by EPO-treatment. Taken together, EPO-treatment aggravates hypertension in CRF, but altered role of NO system may not be involved.
机译：我们调查了一氧化氮（NO）系统的作用改变是否与促红细胞生成素（EPO）诱发的慢性肾功能衰竭（CRF）高血压有关。将六分之五的肾切除的雄性Sprague-Dawley大鼠诱发CRF。手术六周后，再注射EPO或媒介物6周。确定血浆和尿液中亚硝酸盐/硝酸盐（NOx）的水平。还确定了主动脉和肾脏中NO合酶（NOS）蛋白的表达。另外，检查了对乙酰胆碱和硝普钠响应的孤立主动脉的等轴测张力。 CRF组的血压逐渐升高，EPO治疗使血压升高。各组血浆NOx水平无差异，而CRF组尿NOx水平较低。在CRF大鼠中，肾脏和主动脉中内皮NOS的表达较低，这不受EPO处理的影响。各组之间在肾脏和主动脉中诱导型NOS表达没有差异。乙酰胆碱和硝普钠可引起剂量依赖性的主动脉环松弛，其程度不会因EPO处理而改变。综上所述，EPO治疗加重了CRF中的高血压，但未涉及NO系统作用的改变。

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