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首页> 美国卫生研究院文献>Journal of Korean Medical Science >Tissue plasminogen activator and plasminogen activator inhibitor type 1 gene polymorphism in patients with gastric ulcer complicated with bleeding.
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Tissue plasminogen activator and plasminogen activator inhibitor type 1 gene polymorphism in patients with gastric ulcer complicated with bleeding.

机译：胃溃疡并出血患者的组织纤溶酶原激活物和纤溶酶原激活物抑制剂1型基因多态性。

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Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) may be involved in the pathogenesis of peptic ulcers through suppression of fibrinolysis. This study was designed to investigate associations of t-PA and PAI-1 genes with clinical features of the patients with bleeding gastric ulcers. Eighty-four patients with peptic ulcers and 100 controls were studied between January 1998 and April 2000. We used polymerase chain reaction and endonuclease digestion to genotype for 4G/5G polymorphism in the promoter region of the PAI-1 gene and the Alurepeat insertion/deletion (I/D) polymorphism in intron h of the t-PA gene. Various clinical features, including lesion site, bleeding event, recurrence of ulcer, and rebleeding, were assessed using a multiple logistic regression model. The genotype distributions of both the t-PA and PAI-1 genes did not differ between the patient and control groups. The occurrence of the I/D or D/D genotype of t-PA was significantly higher in cases of duodenal ulcer (adjusted OR=4.39, 95% CI=1.12-17.21). When a dominant effect (i.e., 4G/4G or 4G/5G versus 5G/5G) of the 4G allele was assumed, the PAI-1 4G/4G genotype was independently associated with rebleeding after hemostasis (adjusted OR=5.07, 95% CI=1.03-24.87). Our data suggest that t-PA gene polymorphism is associated with duodenal ulcers, and that the PAI-1 gene may be a risk factor leading to recurrent bleeding after initial hemostasis.
机译：组织纤溶酶原激活物（t-PA）和纤溶酶原激活物抑制剂1型（PAI-1）可能通过抑制纤维蛋白溶解而参与了消化性溃疡的发病过程。本研究旨在研究t-PA和PAI-1基因与胃溃疡出血患者临床特征的相关性。在1998年1月至2000年4月之间，对84例消化性溃疡患者和100例对照进行了研究。我们使用聚合酶链反应和核酸内切酶消化法对PAI-1基因启动子区域和Alurepeat插入/缺失的4G / 5G多态性进行了基因分型。 t-PA基因内含子的（I / D）多态性。使用多元逻辑回归模型评估了各种临床特征，包括病变部位，出血事件，溃疡复发和再出血。患者和对照组之间t-PA和PAI-1基因的基因型分布没有差异。在十二指肠溃疡的情况下，t-PA I / D或D / D基因型的发生率显着更高（OR = 4.39，95％CI = 1.12-17.21）。当假设4G等位基因具有显性作用（即4G / 4G或4G / 5G与5G / 5G相比）时，PAI-1 4G / 4G基因型与止血后再出血独立相关（校正OR = 5.07，CI为95％） = 1.03-24.87）。我们的数据表明，t-PA基因多态性与十二指肠溃疡有关，而PAI-1基因可能是导致最初止血后再次出血的危险因素。

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