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Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution

机译:时域漫射光学成像差分数据的线性3D重建:改进的深度定位和横向分辨率

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摘要

We present 3D linear reconstructions of time-domain (TD) diffuse optical imaging differential data. We first compute the sensitivity matrix at different delay gates within the diffusion approximation for a homogeneous semi-infinite medium. The matrix is then inverted using spatially varying regularization. The performances of the method and the influence of a number of parameters are evaluated with simulated data and compared to continuous-wave (CW) imaging. In addition to the expected depth resolution provided by TD, we show improved lateral resolution and localization. The method is then applied to reconstructing phantom data consisting of an absorbing inclusion located at different depths within a scattering medium.
机译:我们提出了时域(TD)漫射光学成像差分数据的3D线性重建。我们首先计算均匀半无限介质的扩散近似内不同延迟门处的灵敏度矩阵。然后使用空间变化的正则化对矩阵进行反转。使用模拟数据评估该方法的性能以及许多参数的影响,并将其与连续波(CW)成像进行比较。除了TD提供的预期深度分辨率外,我们还显示了改进的横向分辨率和定位。然后将该方法应用于重建体模数据,该体模数据由位于散射介质内不同深度的吸收性包裹体组成。

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