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首页> 美国卫生研究院文献>Optics Express >Development and application of a ray-based model of light propagation through a spherical acousto-optic lens
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Development and application of a ray-based model of light propagation through a spherical acousto-optic lens

机译：基于射线的球面声光透镜传播模型的开发和应用

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A spherical acousto-optic lens (AOL) consists of four acousto-optic deflectors (AODs) that can rapidly and precisely control the focal position of an optical beam in 3D space. Development and application of AOLs has increased the speed at which 3D random access point measurements can be performed with a two-photon microscope. This has been particularly useful for measuring brain activity with fluorescent reporter dyes because neuronal signalling is rapid and sparsely distributed in 3D space. However, a theoretical description of light propagation through AOLs has lagged behind their development, resulting in only a handful of simplified principles to guide AOL design and optimization. To address this we have developed a ray-based computer model of an AOL incorporating acousto-optic diffraction and refraction by anisotropic media. We extended an existing model of a single AOD with constant drive frequency to model a spherical AOL: four AODs in series driven with linear chirps. AOL model predictions of the relationship between optical transmission efficiency and acoustic drive frequency including second order diffraction effects closely matched experimental measurements from a 3D two-photon AOL microscope. Moreover, exploration of different AOL drive configurations identified a new simple rule for maximizing the field of view of our compact AOL design. By providing a theoretical basis for understanding optical transmission through spherical AOLs, our open source model is likely to be useful for comparing and improving different AOL designs, as well as identifying the acoustic drive configurations that provide the best transmission performance over the 3D focal region.
机译：球形声光透镜（AOL）由四个声光偏转器（AOD）组成，它们可以快速而精确地控制3D空间中光束的焦点位置。 AOL的开发和应用提高了使用双光子显微镜进行3D随机访问点测量的速度。这对于使用荧光报告染料测量大脑活动特别有用，因为神经元信号快速且稀疏地分布在3D空间中。但是，对通过AOL传播的光的理论描述已落后于其发展，因此仅产生了一些简化的原理来指导AOL设计和优化。为了解决这个问题，我们开发了一种基于AOL射线的计算机模型，该模型结合了各向异性介质的声光衍射和折射。我们扩展了具有恒定驱动频率的单个AOD的现有模型，以对球形AOL进行建模：四个线性线性调频驱动的AOD串联。 AOL模型对光传输效率和声学驱动频率之间关系的预测（包括二阶衍射效应）与3D两光子AOL显微镜的实验测量值非常匹配。此外，对不同AOL驱动器配置的探索确定了一条新的简单规则，可最大限度地提高我们紧凑AOL设计的视野。通过为理解通过球形AOL的光传输提供理论基础，我们的开放源代码模型可能有助于比较和改进不同的AOL设计，并确定在3D聚焦区域提供最佳传输性能的声学驱动器配置。

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