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首页> 美国卫生研究院文献>Molecular and Clinical Oncology >Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker
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Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker

机译：服用5-氨基乙酰丙酸作为潜在的肿瘤标志物后血浆原卟啉IX

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Exogenously administered 5-aminolevulinic acid (ALA) is metabolized to protoporphyrin IX (PpIX), which specifically accumulates in cancer cells and emits red fluorescence by blue light irradiation. These phenomena are applied for the intraoperative diagnosis of cancer. Based on the fact that accumulated PpIX in cancer cells is exported extracellularly via the ATP-binding cassette transporter G2, we hypothesized that the measurement of plasma PpIX concentrations could be applied as a tumor marker for cancer screening. In the present study, the use of plasma samples from bladder cancer patients were evaluated as a tumor marker. ALA, 1.0 g, was orally administered to bladder cancer patients and healthy adults. The plasma concentration of PpIX was measured using a high-performance liquid chromatography system. The plasma PpIX concentration following ALA administration was significantly higher in bladder cancer patients than that in the healthy adults, suggesting the effectiveness of plasma PpIX analysis following ALA administration for cancer screening. Additionally, 4 h after ALA administration, plasma PpIX showed high sensitivity (94.4%) and high specificity (80.0%).
机译：外用的5-氨基乙酰丙酸（ALA）代谢为原卟啉IX（PpIX），原卟啉IX专门积聚在癌细胞中，并通过蓝光照射发出红色荧光。这些现象被用于癌症的术中诊断。基于癌细胞中积累的PpIX通过ATP结合盒转运蛋白G2胞外输出这一事实，我们假设血浆PpIX浓度的测量可以用作癌症筛查的肿瘤标志物。在本研究中，评估了膀胱癌患者血浆样本的使用作为肿瘤标志物。向膀胱癌患者和健康成年人口服1.0 g ALA。使用高效液相色谱系统测量PpIX的血浆浓度。膀胱癌患者中ALA给药后血浆PpIX浓度显着高于健康成年人，这表明ALA给药后血浆PpIX分析对癌症筛查的有效性。此外，ALA给药后4小时，血浆PpIX表现出高灵敏度（94.4％）和高特异性（80.0％）。

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