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首页> 美国卫生研究院文献>Rheumatology (Oxford England) >The Canadian Systemic Sclerosis Oral Health Study II: the relationship between oral and global health-related quality of life in systemic sclerosis
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The Canadian Systemic Sclerosis Oral Health Study II: the relationship between oral and global health-related quality of life in systemic sclerosis

机译：加拿大系统性硬化症口腔健康研究II：系统性硬化症中口腔健康与全球健康相关生活质量之间的关系

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>Objective. Both oral and global health-related quality of life (HRQoL) are markedly impaired in SSc. In this study we aimed to determine the degree of association between oral HRQoL and global HRQoL in SSc.>Methods. Subjects were recruited from the Canadian Scleroderma Research Group registry. Global HRQoL was measured using the Medical Outcomes Trust 36-item Short Form Health Survey (SF-36) and oral HRQoL with the Oral Health Impact Profile (OHIP). The Medsger Disease Severity Score was used to determine organ involvement. Multivariate regression models determined the independent association of the OHIP with the SF-36 after adjusting for confounders.>Results. This study included 156 SSc subjects. The majority (90%) were women, with a mean age of 56 years, mean disease duration 13.8 years (s.d. 8.5) and 29% of the subjects had dcSSc. Mean total OHIP score was 40.8 (s.d. 32.4). Mean SF-36 mental component summary (MCS) score was 49.7 (s.d. 11.1) and physical component summary (PCS) score was 37.0 (s.d. 10.7). In adjusted analyses, the total OHIP score was significantly associated with the SF-36 MCS and PCS, accounting for 9.7% and 5.6% of their respective variances. Measures of disease severity were not related to OHIP score.>Conclusion. Oral HRQoL in SSc is independently associated with global HRQoL. Oral HRQoL, however, is not related to physician-assessed disease severity. This suggests that physicians may be disregarding issues related to oral health. HRQoL is an additional dimension of HRQoL not captured by generic instruments such as the SF-36.
机译：>目标。SSc严重损害了与口腔和全球健康相关的生活质量（HRQoL）。在本研究中，我们旨在确定SSc中口服HRQoL与整体HRQoL之间的关联程度。>方法。。受试者从加拿大硬皮病研究组注册表中招募。全球HRQoL使用“医学成果信任度” 36个项目的简短健康调查（SF-36）和具有口腔健康影响档案（OHIP）的口服HRQoL进行测量。 Medsger疾病严重程度评分用于确定器官受累情况。多元回归模型确定了混杂因素后，OHIP与SF-36的独立关联。>结果。该研究纳入156名SSc受试者。多数（90％）是女性，平均年龄为56岁，平均病程为13.8年（标准8.5），其中29％的受试者患有dcSSc。 OHIP总平均得分为40.8（标准差32.4）。 SF-36的心理成分摘要（MCS）平均得分为49.7（标准11.1），物理成分摘要（PCS）分数为37.0（标准10.7）。在调整后的分析中，总OHIP得分与SF-36 MCS和PCS显着相关，分别占其各自差异的9.7％和5.6％。疾病严重程度的测量与OHIP评分无关。>结论。SSc的口服HRQoL与总体HRQoL独立相关。但是，口服HRQoL与医生评估的疾病严重程度无关。这表明医生可能会忽略与口腔健康有关的问题。 HRQoL是HRQoL的附加维度，未被SF-36等通用工具捕获。

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