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首页> 美国卫生研究院文献>Journal of Korean Medical Science >Associations between Oxidized LDL to LDL Ratio HDL and Vascular Calcification in the Feet of Hemodialysis Patients
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Associations between Oxidized LDL to LDL Ratio HDL and Vascular Calcification in the Feet of Hemodialysis Patients

机译：血液透析患者脚中氧化型低密度脂蛋白与低密度脂蛋白的比率高密度脂蛋白与血管钙化的关系

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摘要

Cardiovascular mortality is associated with vascular calcification (VC) in hemodialysis (HD) patients. The present study was designed to find factors related with medial artery calcification on the plain radiography of feet by comparing C-reactive protein (CRP), plasminogen activator inhibitor type 1 (PAI-1) and lipid profile including oxidized low density lipoprotein (ox-LDL) and to elucidate associations among these factors in HD patients. Forty-eight HD patients were recruited for this study. VC in the feet was detected in 18 patients (37.5%) among total patients and 12 patients (85.7%) among diabetic patients. Diabetes, cardiovascular disease (CVD), pulse pressure, ox-LDL/LDL were higher and high density lipoprotein (HDL) was lower in patients with VC than in patients without VC. Negative associations were found between HDL and CRP, PAI-1. PAI-1 had positive association with ox-LDL/LDL. History of CVD was the only determinant of vascular calcification on the plain radiography of feet. Ox-LDL/LDL, HDL, CRP, and PAI-1 were closely related with one another in HD patients. History of CVD is the most important factor associated with the presence of VC and low HDL and relatively high oxidized LDL/LDL ratio may affect VC formation on the plain radiography in the feet of HD patients.
机译：血液透析（HD）患者的心血管死亡率与血管钙化（VC）相关。本研究旨在通过比较C反应蛋白（CRP），1型纤溶酶原激活物抑制剂（PAI-1）和脂质分布（包括氧化的低密度脂蛋白（ox- LDL）并阐明HD患者中这些因素之间的关联。本研究招募了48名HD患者。在所有患者中，有18例患者（37.5％）和糖尿病患者中有12例患者（85.7％）检测到脚部VC。 VC患者的糖尿病，心血管疾病（CVD），脉压，ox-LDL / LDL较高，而无VC患者的高密度脂蛋白（HDL）较低。在HDL与CRP，PAI-1之间发现负相关。 PAI-1与ox-LDL / LDL呈正相关。 CVD的历史是脚部平片上血管钙化的唯一决定因素。在HD患者中，Ox-LDL / LDL，HDL，CRP和PAI-1彼此密切相关。 CVD的病史是与VC和低HDL的存在相关的最重要因素，并且相对较高的氧化LDL / LDL比值可能会影响HD患者脚部平片上VC的形成。

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