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首页> 美国卫生研究院文献>European Radiology Experimental >Microbubbles as a contrast agent in grating interferometry mammography: an ex vivo proof-of-mechanism study
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Microbubbles as a contrast agent in grating interferometry mammography: an ex vivo proof-of-mechanism study

机译：微气泡作为光栅干涉X线摄影术中的造影剂：离体机制研究

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Grating interferometry mammography (GIM) is an experimental breast imaging method at the edge of being clinically implemented. Besides attenuation, GIM can measure the refraction and scattering of x-rays resulting in differential phase contrast (DPC) and dark-field (DF) images. In this exploratory study, we assessed the feasibility of using microbubbles as a contrast agent in GIM. Two millilitres of microbubbles and iodine were respectively injected into ex vivo breast phantoms, consisting of fresh chicken breasts. Native and postcontrast images were acquired with a clinically compatible GIM setup, operated at 38 kVp, 14-s acquisition time, and with a dose of 1.3 mGy. The visibility of the contrast agents was analysed in a side-by-side comparison by three radiologists. The contrast-to-noise-ratio (CNR) was calculated for each contrast agent. We found that both contrast agents were judged to be visible by the readers. The mean CNR was 3.1 ± 1.9 for microbubbles in DF and 24.2 ± 6.5 for iodine in attenuation. In conclusion, this is a first proof-of-mechanism study that microbubbles could be used as a contrast agent in clinically compatible GIM, due to their scattering properties, which implies the potential use of a contrast agent with a high safety profile in x-ray-based breast imaging.
机译：光栅干涉乳腺摄影（GIM）是一种在临床上尚处于边缘的实验性乳房成像方法。除了衰减之外，GIM还可以测量X射线的折射和散射，从而产生差分相衬（DPC）和暗场（DF）图像。在这项探索性研究中，我们评估了在GIM中使用微泡作为造影剂的可行性。将两毫升微泡和碘分别注射到由新鲜鸡胸肉组成的离体乳腺模型中。原始和对比度图像是通过临床兼容的GIM设置采集的，以38kVp的速度运行，采集时间为14秒，剂量为1.3μmGy。三名放射科医生在并排比较中分析了造影剂的可见性。计算每种造影剂的对比噪声比（CNR）。我们发现两种造影剂均被读者视为可见。 DF中微气泡的平均CNR为3.1±1.9，而碘衰减的平均CNR为24.2±6.5。总而言之，这是第一个机理证明研究，因为微泡具有散射特性，因此可以在临床上兼容的GIM中用作造影剂，这意味着潜在地使用具有高安全性的造影剂在x-基于射线的乳房成像。

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