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首页> 美国卫生研究院文献>Journal of Surgical Case Reports >When breast cancer gets complicated. A case report of synchronous bilateral breast cancers with discordant tumor markers from the primary to nodes with findings of a sentinel internal mammary subpectoral lymph node
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When breast cancer gets complicated. A case report of synchronous bilateral breast cancers with discordant tumor markers from the primary to nodes with findings of a sentinel internal mammary subpectoral lymph node

机译：当乳腺癌变得复杂时。一例同步性双侧乳腺癌其肿瘤标志物从原发到淋巴结不等并伴有前哨内部乳腺胸膜下淋巴结的发现

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This case reviews synchronous bilateral breast cancer with left infiltrating ductal carcinoma ER+/PR−, Her2− and right invasive lobular carcinoma ER+/PR−, Her2−. Independent primary bilateral breast tumors are present in 0.2–3.2% of breast cancer. Biopsy also showed differing ER status on the left breast versus the node which was triple negative. The final sentinel node was a left internal mammary node. Recent studies have found that the ER, PR and HER2 status of the primary tumor do not always correlate to the ER, PR and HER2 status of the metastatic sites. This can have deleterious effects on survival. There are no clear guidelines on course of treatment for these complex cases. A review of the current literature is supportive of treating the highest-risk breast malignancy. Despite the unusual pathology and severity of disease, our patient is doing well with treatment.
机译：该病例回顾了伴有左浸润性导管癌ER + / PR-，Her2-和右浸润性小叶癌ER + / PR-，Her2-的同步性双侧乳腺癌。独立的原发性双侧乳腺肿瘤占乳腺癌的0.2–3.2％。活检还显示左乳腺与淋巴结的ER状态不同，为三阴性。最后的前哨淋巴结是左内部乳腺淋巴结。最近的研究发现，原发性肿瘤的ER，PR和HER2状态并不总是与转移部位的ER，PR和HER2状态相关。这可能对生存产生有害影响。对于这些复杂病例，没有明确的治疗过程指南。对当前文献的回顾支持治疗最高风险的乳腺恶性肿瘤。尽管病理和疾病严重程度不同，但我们的患者治疗情况良好。

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