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Effects of Insulin Degludec and Insulin Glargine U300 on Day-to-Day Fasting Plasma Glucose Variability in Individuals with Type 1 Diabetes: A Multicenter Randomized Crossover Study (Kobe Best Basal Insulin Study 2)

机译：胰岛素Degludec和甘精胰岛素U300对1型糖尿病患者日常空腹血浆葡萄糖变异性的影响：一项多中心随机交叉研究（Kobe Best Basal Insulin Study 2）

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IntroductionAdministered basal insulin markedly influences the fasting plasma glucose (FPG) level of individuals with type 1 diabetes. Insulin degludec (IDeg) and insulin glargine U300 (IGlar U300) are now available as ultra-long-acting insulin formulations, but whether or how their glucose-stabilizing effects differ remains unclear. We will compare the effects of these basal insulins on parameters related to blood glucose control, with a focus on day-to-day glycemic variability, in individuals with type 1 diabetes treated with multiple daily injections.

机译：简介基础胰岛素的给药显着影响1型糖尿病患者的空腹血糖（FPG）水平。地格曲胰岛素（IDeg）和甘精胰岛素U300（IGlar U300）现在可以作为超长效胰岛素制剂使用，但它们的葡萄糖稳定作用是否不同或如何差别尚不清楚。我们将比较这些基础胰岛素对每天多次注射治疗的1型糖尿病患者血糖控制相关参数的影响，重点是日常血糖变异性。

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期刊名称 Diabetes Therapy
作者
Hiroshi Miura; Kazuhiko Sakaguchi; Yuko Okada; Natsu Otowa-Suematsu; Tomoko Yamada; Anna So; Hisako Komada; Yushi Hirota; Minoru Kishi; Akihiko Takeda; Yoichi Tominaga; Tomoaki Nakamura; Yasuo Kuroki; Tomokazu Matsuda; Keiji Iida; Michiko Kajikawa; Takeshi Ohara; Kazuki Yokota; Kenta Hara; Sanshiro Tateya; Yoshikazu Tamori; Wataru Ogawa;
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年(卷),期 2018(9),6
年度 2018
页码 2399–2406
总页数 8
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Basal-bolus insulin therapy Day-to-day fasting plasma glucose variability Insulin degludec Insulin glargine U300 Type 1 diabetes;

机译：基础大剂量胰岛素治疗;每日空腹血浆葡萄糖变异性;地高胰岛素;甘精胰岛素U300、1型糖尿病;

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1. Effects of Insulin Degludec and Insulin Glargine U300 on Day-to-Day Fasting Plasma Glucose Variability in Individuals with Type 1 Diabetes: A Multicenter, Randomized, Crossover Study (Kobe Best Basal Insulin Study 2) [J] . Hiroshi Miura, Kazuhiko Sakaguchi, Yuko Okada, Diabetes therapy . 2018,第6期

机译：胰岛素Degludec和甘精胰岛素U300对1型糖尿病患者日常空腹血浆葡萄糖变异性的影响：一项多中心，随机，交叉研究（Kobe Best Basal Insulin Study 2）
2. Effects of insulin degludec and insulin glargine on day-to-day fasting plasma glucose variability in individuals with type 1 diabetes: a multicentre, randomised, crossover study [J] . Tomoaki Nakamura, Kazuhiko Sakaguchi, Anna So, Diabetologia: clinical and experimental diabetes and metabolism . 2015,第9期

机译：地格曲胰岛素和甘精胰岛素对1型糖尿病患者每日空腹血浆葡萄糖变异性的影响：一项多中心，随机，交叉研究
3. Effects of insulin degludec and insulin glargine on day-to-day fasting plasma glucose variability in individuals with type 1 diabetes: a multicentre, randomised, crossover study [J] . Tomoaki Nakamura, Kazuhiko Sakaguchi, Anna So, Diabetologia: clinical and experimental diabetes and metabolism . 2015,第9期

机译：地格曲胰岛素和甘精胰岛素对1型糖尿病患者每日空腹血浆葡萄糖变异性的影响：一项多中心，随机，交叉研究
4. Insulin Degludec, Insulin Glargine U300, and Other Novel Insulin Formulations [C] . American College of Veterinary Internal Medicine Forum Conference . 2018

机译：胰岛素Degludec，胰岛素甘氨酸U300等新型胰岛素配方
5. A study of the effects of insulin-based fibre supplementation on serum glucose and lipid concentrations of individuals with type 2 diabetes [D] . Bonsu, Nana Kofi Afum 2010

机译：补充胰岛素纤维对2型糖尿病患者血糖和血脂浓度影响的研究
6. Effects of insulin degludec and insulin glargine on day-to-day fasting plasma glucose variability in individuals with type 1 diabetes: a multicentre randomised crossover study [O] . Tomoaki Nakamura, Kazuhiko Sakaguchi, Anna So, -1

机译：地格曲胰岛素和甘精胰岛素对1型糖尿病患者日常空腹血浆葡萄糖变异性的影响：一项多中心随机交叉研究
7. Effects of insulin degludec and insulin glargine on day-to-day fasting plasma glucose variability in individuals with type 1 diabetes: a multicentre, randomised, crossover study [O] . Tomoaki Nakamura, Kazuhiko Sakaguchi, Anna So, 2015

机译：地格曲胰岛素和甘精胰岛素对1型糖尿病患者日常空腹血浆葡萄糖变异性的影响：一项多中心，随机，交叉研究

Effects of Insulin Degludec and Insulin Glargine U300 on Day-to-Day Fasting Plasma Glucose Variability in Individuals with Type 1 Diabetes: A Multicenter Randomized Crossover Study (Kobe Best Basal Insulin Study 2)

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