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首页> 美国卫生研究院文献>DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes >Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation
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Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation

机译：美国黑熊的基因组组装和基因表达为了解冬眠的肾脏反应提供了新的见解

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摘要

The prevalence of chronic kidney disease (CKD) is rising worldwide and 10–15% of the global population currently suffers from CKD and its complications. Given the increasing prevalence of CKD there is an urgent need to find novel treatment options. The American black bear (Ursus americanus) copes with months of lowered kidney function and metabolism during hibernation without the devastating effects on metabolism and other consequences observed in humans. In a biomimetic approach to better understand kidney adaptations and physiology in hibernating black bears, we established a high-quality genome assembly. Subsequent RNA-Seq analysis of kidneys comparing gene expression profiles in black bears entering (late fall) and emerging (early spring) from hibernation identified 169 protein-coding genes that were differentially expressed. Of these, 101 genes were downregulated and 68 genes were upregulated after hibernation. Fold changes ranged from 1.8-fold downregulation (RTN4RL2) to 2.4-fold upregulation (CISH). Most notable was the upregulation of cytokine suppression genes (SOCS2, CISH, and SERPINC1) and the lack of increased expression of cytokines and genes involved in inflammation. The identification of these differences in gene expression in the black bear kidney may provide new insights in the prevention and treatment of CKD.
机译：世界范围内慢性肾脏病（CKD）的患病率正在上升，目前全球人口的10-15％患有CKD及其并发症。鉴于CKD的患病率不断上升，迫切需要寻找新的治疗选择。美国黑熊（Ursus americanus）可以应付数月的冬眠期间肾功能和新陈代谢降低，而不会破坏人体的新陈代谢和其他后果。为了更好地了解冬眠黑熊的肾脏适应性和生理机制，我们采用仿生方法建立了高质量的基因组组装体。随后的肾脏RNA-Seq分析比较了黑熊从冬眠进入（秋季）和从冬眠（春季初）的基因表达谱，鉴定出了169个差异表达的蛋白质编码基因。其中，休眠后101个基因被下调，而68个基因被上调。倍数变化范围从1.8倍下调（RTN4RL2）到2.4倍上调（CISH）。最值得注意的是细胞因子抑制基因（SOCS2，CISH和SERPINC1）的上调和缺乏涉及炎症的细胞因子和基因表达的增加。在黑熊肾脏中基因表达的这些差异的鉴定可能为CKD的预防和治疗提供新的见解。

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