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Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

机译:传统中医药作为一种癌症治疗方法:古代但先进科学的现代观点

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摘要

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine‐derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. In addition, the impact of TCM treatment on DNA methylation, histone modification, and the regulation of noncoding RNAs is discussed. Furthermore, we have highlighted studies of TCM therapy that modulate the tumor microenvironment and eliminate cancer stem cells. The information compiled in this review will serve as a solid foundation to formulate hypotheses for future studies on TCM‐based cancer therapy.
机译:中医(TCM)已经实践了数千年,目前已被广泛接受为癌症的替代疗法。在这篇综述中,我们试图总结中药化学预防和治疗活性的分子和细胞机制,尤其是中草药来源的植物化学物质姜黄素,白藜芦醇和小ber碱的分子和细胞机制。据报道,使用中医治疗时涉及许多基因,因此我们选择性地强调了许多癌基因和抑癌基因在中医治疗中的作用。此外,还讨论了中药治疗对DNA甲基化,组蛋白修饰和非编码RNA调控的影响。此外,我们已经着重研究了中医疗法的研究,该疗法可调节肿瘤微环境并消除癌症干细胞。本综述中收集的信息将为为基于中医的癌症治疗的未来研究提出假设奠定坚实的基础。

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