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首页> 美国卫生研究院文献>AAPS PharmSciTech >Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tartrate Delivery Systems
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Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tartrate Delivery Systems

机译：酒石酸美托洛尔持续输送体系中各种组成的含聚（2-乙基-2-恶唑啉）共聚物网络的评估

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摘要

Segmented copolymer networks (SCN) based on poly(2-ethyl-2-oxazoline) and containing 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, and/or methyl methacrylate segments have been evaluated as potential sustained release systems of the water soluble cardioselective β-blocker metoprolol tartrate. The structure and properties of the drug carriers were investigated by differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. Swelling kinetics of SCNs in various media was followed, and the conditions for effective MT loading were specified. MT-loaded SCNs with drug content up to 80 wt.% were produced. The release kinetics of metoprolol tartrate from the systems was studied and it was shown that the conetworks of different structure and composition are able to sustain the metoprolol tartrate release without additional excipients.
机译：已经评估了基于聚（2-乙基-2-恶唑啉）并包含甲基丙烯酸2-羟乙酯，丙烯酸2-羟丙酯和/或甲基丙烯酸甲酯链段的嵌段共聚物网络（SCN），作为水溶性心脏选择性β的潜在缓释系统-阻滞剂美托洛尔酒石酸盐。通过差示扫描量热，衰减全反射傅立叶变换红外光谱，扫描电子显微镜和原子力显微镜研究了药物载体的结构和性质。遵循SCNs在各种介质中的溶胀动力学，并规定了有效MT负载的条件。产生了MT含量高达80％（重量）的SCN。研究了酒石酸美托洛尔从体系中的释放动力学，结果表明，不同结构和组成的共网络能够维持酒石酸美托洛尔的释放而无需其他赋形剂。

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