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A latent class approach to identify multi‐risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015

机译:一种潜在类别方法用于确定与2004年至2015年间澳大利亚和新西兰最近发生的丙型肝炎病毒感染的系统发生聚类相关的多风险特征

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摘要

IntroductionOver the last two decades, the incidence of hepatitis C virus (HCV) co‐infection among men who have sex with men (MSM) living with HIV began increasing in post‐industrialized countries. Little is known about transmission of acute or recent HCV, in particular among MSM living with HIV co‐infection, which creates uncertainty about potential for reinfection after HCV treatment. Using phylogenetic methods, clinical, epidemiological and molecular data can be combined to better understand transmission patterns. These insights may help identify strategies to reduce reinfection risk, enhancing effectiveness of HCV treatment as prevention strategies. The aim of this study was to identify multi‐risk profiles and factors associated with phylogenetic pairs and clusters among people with recent HCV infection.
机译:简介在过去的二十年中,在工业化后的国家中,男男性接触者(HIV)感染丙型肝炎病毒(HCV)的感染率开始上升。关于急性或近期HCV的传播知之甚少,尤其是在患有HIV合并感染的MSM中,这使HCV治疗后再次感染的可能性不确定。使用系统发育方法,可以结合临床,流行病学和分子数据,以更好地了解传播方式。这些见解可能有助于确定降低再感染风险的策略,增强HCV治疗作为预防策略的有效性。这项研究的目的是确定近期HCV感染者的多重风险特征和与系统发育对和簇相关的因素。

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