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首页> 美国卫生研究院文献>Schizophrenia Bulletin >7.2 ELECTRORETINOGRAPHIC ANOMALIES SEEN IN PATIENTS AFFECTED BY SCHIZOPHRENIA OR BIPOLAR DISORDER ARE DETECTABLE EARLY IN CHILDREN BORN TO AN AFFECTED PARENT: IMPLICATIONS FOR THE STAGING OF RISK STATUS IN CHILDHOOD-ADOLESCENCE
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7.2 ELECTRORETINOGRAPHIC ANOMALIES SEEN IN PATIENTS AFFECTED BY SCHIZOPHRENIA OR BIPOLAR DISORDER ARE DETECTABLE EARLY IN CHILDREN BORN TO AN AFFECTED PARENT: IMPLICATIONS FOR THE STAGING OF RISK STATUS IN CHILDHOOD-ADOLESCENCE

机译：7.2患精神分裂症或双歧疾病的患者出现的视网膜电图异常可在患儿父母中早期发现：对儿童失语症的危险状态有明显影响

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BackgroundAdult patients having schizophrenia, bipolar disorder or major depression display indicators of brain dysfunctions that may be detectable in healthy children-adolescents at genetic risk, such as those born to an affected parent (Maziade, New Eng J Med 2017; Schizophr Res 2013). For instance, cognitive deficits are displayed by both adult patients and children at risk (Maziade, Schizophr Bull 2011). We had reported that schizophrenia patients present diminished amplitudes and delayed latencies of rod and cone photoreceptor responses (Hébert, Schizophr Res, 2015) and we recently found that bipolar patients have similar ERG anomalies. We had also reported preliminary data in a small sample of 29 children born to an affected parent showing that young offspring had rod diminished amplitudes (Hébert, Biol Psychiatry 2010).The present objectives were i) under the hypothesis that offspring would display many of the ERG anomalies that schizophrenia or mood disorder patients carry (Hébert, Schizophr Res 2015; Prog Neuropsychopharmacol Biol Psychiatry 2017), to look for cone and rod response anomalies in a large sample of young high-risk offspring; ii) to describe the relationship between ERG anomalies and other risk endophenotypes in the offspring; and iii) look at the relationship between ERG anomalies and the risk clusters already shown to predict later transition to illness.
机译：背景患有精神分裂症，躁郁症或重度抑郁症的成人患者显示出大脑功能障碍的指标，这些指标在健康的儿童中-遗传风险中的青少年，例如患父母的婴儿中可以检测到（Maziade，New Eng J Med 2017; Schizophr Res 2013）。例如，成年患者和处于危险中的儿童都表现出认知缺陷（Maziade，Schizophr Bull 2011）。我们曾报道精神分裂症患者的视杆和视锥光感受器反应幅度降低且延迟潜伏期（Hébert，Schizophr Res，2015），我们最近发现双相情感障碍患者的ERG异常相似。我们还报道了29个患病父母的孩子的小样本的初步数据，这些数据表明年轻后代的杆幅度减小了（Hébert，Biol Psychiatry 2010）。目前的目标是i）假设后代会显示许多精神分裂症或情绪障碍患者携带的ERG异常（Hébert，Schizophr Res 2015; Prog Neuropsychopharmacol Biol Psychiatry 2017），以在大量年轻的高风险后代中寻找锥体和杆状反应异常; ii）描述后代ERG异常与其他危险内表型之间的关系； iii）研究ERG异常与已经显示出可预测以后向疾病过渡的风险群之间的关系。

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