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首页> 美国卫生研究院文献>Journal of Lasers in Medical Sciences >Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats
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Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats

机译：3 Hz和60 Hz极低频电磁场对雄性大鼠的焦虑样行为被动回避记忆力和电生理特性的影响

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>Introduction: The effects of electromagnetic fields on biological organisms have been a controversial and also interesting debate over the past few decades, despite the wide range of investigations, many aspects of extremely low frequency electromagnetic fields (ELF/EMFs) effects including mechanism of their interaction with live organisms and also their possible biological applications still remain ambiguous. In the present study, we investigated whether the exposures of ELF/EMF with frequencies of 3 Hz and 60 Hz can affect the memory, anxiety like behaviors, electrophysiological properties and brain’s proteome in rats. >Methods: Male rats were exposed to 3 Hz and 60 Hz ELF/EMFs in a protocol consisting of 2 cycles of 2 h/day exposure for 4 days separated with a 2-day interval. Short term memory and anxiety like behaviors were assessed immediately, 1 and 2 weeks after the exposures. Effects of short term exposure were also assessed using electrophysiological approach immediately after 2 hours exposure. >Results: Behavioral test revealed that immediately after the end of exposures, locomotor activity of both 3 Hz and 60 Hz exposed groups significantly decreased compared to sham group. This exposure protocol had no effect on anxiety like behavior during the 2 weeks after the treatment and also on short term memory. A significant reduction in firing rate of locus coeruleus (LC) was found after 2 hours of both 3 Hz and 60 Hz exposures. Proteome analysis also revealed global changes in whole brain proteome after treatment. >Conclusion: Here, some evidence regarding the fact that such exposures can alter locomotor activity and neurons firing rate in male rats were presented.
机译：>简介：尽管进行了广泛的研究，但极低频电磁场（ELF / EMFs）的许多方面，电磁场对生物的影响在过去的几十年中一直是一个有争议且有趣的辩论。 ）效应，包括它们与活生物体相互作用的机制，以及它们可能的生物学应用，仍然不明确。在本研究中，我们调查了频率为3 Hz和60 Hz的ELF / EMF暴露是否会影响大鼠的记忆力，焦虑症（如行为），电生理特性和大脑蛋白质组。 >方法：将雄性大鼠暴露于3 Hz和60 Hz ELF / EMF，该方案包括2个周期，每天2 h暴露，间隔2天，间隔4天。暴露后1、2周立即评估短期记忆和类似焦虑的行为。暴露2小时后，立即使用电生理方法评估短期暴露的影响。 >结果：行为测试显示，暴露结束后，与假手术组相比，暴露后3 Hz和60 Hz的运动能力均明显降低。该暴露方案对治疗后2周内的焦虑样行为没有影响，也对短期记忆没有影响。在3 Hz和60 Hz的辐射下暴露2小时后，蓝藻（LC）的放电速率显着降低。蛋白质组分析还揭示了治疗后全脑蛋白质组的整体变化。 >结论：在此，提出了一些证据，说明这种暴露可以改变雄性大鼠的运动能力和神经元放电速率。

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