Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells

机译：愈创木酚对大鼠神经元和N2a神经母细胞的生化活性以及细胞毒和遗传毒性作用

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Aim:Neuroblastoma (NB)cells are often used in cancer researches such as glioblastoma cells since they have the potential of high mitotic activity, nuclear pleomorphism, and tumor necrosis. Guaiazulene (GYZ 1,4-dimethyl-7-isopropylazulene)is present in several essential oils of medicinal and aromatic plants. Many studies have reported the cytotoxic effect of GYZ; however, there are no studies that compare such effects between cancer cell lines and normal human cells after treatment with GYZ.

机译：目的：神经母细胞瘤（NB）细胞由于其具有高有丝分裂活性，核多态性和肿瘤坏死的潜力而经常用于癌症研究，例如胶质母细胞瘤细胞。愈创木酚（GYZ 1,4-二甲基-7-异丙基丙烯）存在于药用和芳香植物的几种精油中。许多研究报道了GYZ的细胞毒性作用。然而，尚无研究比较使用GYZ治疗后癌细胞系与正常人细胞之间的这种作用。

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期刊名称 Journal of Intercultural Ethnopharmacology
作者
Basak Togar; Hasan Turkez; Ahmet Hacimuftuoglu; Abdulgani Tatar; Fatime Geyikoglu;
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年(卷),期 2015(4),1
年度 2015
页码 29–33
总页数 5
原文格式 PDF
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Cytotoxicity genotoxicity guaiazulene neuroblastoma single cell gel electrophoresis assay 3-(45 dimetylthiazol -2-yl)-25 diphenlytetrazolium bromide assay;

机译：细胞毒性;遗传毒性;愈创木酚;神经母细胞瘤;单细胞凝胶电泳测定;3-（45二甲噻唑-2-基）-25溴联苯四唑测定;

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专利

1. Guaiazulene: biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells [J] . Batak Toear, Hasan Türkez, Ahmet Hacymüftüoelu, Journal of Intercultural Ethnopharmacology . 2015,第1期

机译：Guaiazulene：对大鼠神经元和N2a神经母细胞的生化活性以及细胞毒性和遗传毒性作用
2. Investigation of In Vitro Cytotoxicity and Genotoxicity of Wintergreen Oil in Rat Primary Neurons and N2a Neuroblastoma Cells [J] . Celik Kubra, Turkez Hasan Journal of Essential Oil-Bearing Plants . 2016,第6期

机译：冬青油对大鼠原代神经元和N2a神经母细胞瘤细胞的体外细胞毒性和基因毒性研究
3. The effect of carvacrol on healthy neurons and N2a cancer cells: some biochemical, anticancerogenicity and genotoxicity studies [J] . Elanur Ayd?n, Hasan Türkez, M. Sait Kele? Cytotechnology . 2014,第1期

机译：香芹酚对健康神经元和N2a癌细胞的影响：一些生化，抗癌性和遗传毒性研究
4. Cytotoxicity and Genotoxic Effects of Organic Extracts from Traffic-Related Particulate Matter in Human Vascular Endothelial Cells [C] . Yu Shang, Lanlan Fan, Ling Zhang International Conference on Energy, Environment and Sustainable Development . 2013

机译：来自人血管内皮细胞交通相关颗粒物质的有机萃取物的细胞毒性和遗传毒性作用
5. P53 alters the cytotoxicity and genotoxicity for oxidized graphene in human B-lymphoblastoid cells. [D] . Petibone, Dayton Matthew. 2016

机译：P53改变了人B淋巴母细胞中氧化石墨烯的细胞毒性和遗传毒性。
6. The effect of carvacrol on healthy neurons and N2a cancer cells: some biochemical anticancerogenicity and genotoxicity studies [O] . Elanur Aydın, Hasan Türkez, M. Sait Keleş 2014

机译：香芹酚对健康神经元和N2a癌细胞的影响：一些生化抗癌性和遗传毒性研究
7. Guaiazulene: biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells [O] . Basak Togar, Hasan Turkez, Ahmet Hacimuftuoglu, 2015

机译：Guaiazulene：生化活性和细胞毒性和基因毒性对大鼠神经元和N2a神经母细胞的影响

Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells

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