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首页> 美国卫生研究院文献>Journal of Intercultural Ethnopharmacology >Solving the puzzle: What is behind our forefathers’ anti-inflammatory remedies?
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Solving the puzzle: What is behind our forefathers’ anti-inflammatory remedies?

机译：解决难题：我们前辈的抗炎药背后是什么？

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摘要

Inflammation is a ubiquitous host response in charge of restoring normal tissue structure and function but is a double-edged sword, as the uncontrolled or excessive process can lead to the injury of host cells, chronic inflammation, chronic diseases, and also neoplastic transformation. Throughout history, a wide range of species has been claimed to have anti-inflammatory effects worldwide. Among them, Angelica sinensis, Tropaeolum majus, Castilleja tenuiflora, Biophytum umbraculum, to name just a few, have attracted the scientific and general public attention in the last years. Efforts have been made to assess their relevance through a scientific method. However, inflammation is a complex interdependent process, and phytomedicines are complex mixtures of compounds with multiple mechanisms of biological actions, which restricts systematic explanation. For this purpose, the omics techniques could prove extremely useful. They provide tools for interpreting and integrating results from both the classical medical tradition and modern science. As a result, the concept of network pharmacology applied to phytomedicines emerged. All of this is a step toward personalized therapy.
机译：炎症是负责恢复正常组织结构和功能的普遍的宿主反应，但是一把双刃剑，因为不受控制的或过度的过程可能导致宿主细胞损伤，慢性炎症，慢性疾病以及肿瘤转化。纵观整个历史，全世界范围内已经有各种各样的物种具有抗炎作用。其中，仅举几例，当归，非洲对虾，卡斯蒂利亚·特里弗洛拉（Castilleja tenuiflora），本草（Biophytum umbraculum）近年来受到了科学界和公众的关注。已经努力通过科学方法来评估它们的相关性。然而，炎症是一个复杂的相互依存的过程，而植物药是具有多种生物作用机制的化合物的复杂混合物，这限制了系统的解释。为此，组学技术可以证明是非常有用的。它们提供了解释和整合古典医学传统和现代科学结果的工具。结果，出现了将网络药理学应用于植物药的概念。所有这些都是迈向个性化治疗的一步。

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