首页> 美国卫生研究院文献>Open Forum Infectious Diseases >Evolution of Antibiotic Tolerance During Oxacillin Daptomycin and Dalbavancin Therapy Results in Breakthrough Staphylococcus aureus Bacteremias

【2h】

Evolution of Antibiotic Tolerance During Oxacillin Daptomycin and Dalbavancin Therapy Results in Breakthrough Staphylococcus aureus Bacteremias

机译：奥沙西林达托霉素和达巴万星治疗过程中抗生素耐受性的演变导致突破性金黄色葡萄球菌细菌血症

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundClinicians can employ suppressive antimicrobial therapy in patients with persistent or relapsing bacteremia. However, bacteria with favorable susceptibility profiles may exhibit antimicrobial tolerance wherein bacteria cannot proliferate yet can survive in high concentrations of antibiotics. The antimicrobial tolerance phenotype can thwart efforts to prevent bacteremia recurrence with prolonged exposure to antimicrobials and may contribute to breakthrough bacteremias while the patient is receiving active therapy. Here we present a patient case consisting of multiple episodes of breakthrough Staphylococcus aureus bacteremia over several years in the setting of appropriately dosed antimicrobial suppressive therapy and describe organism mutations that developed during therapy.

机译：背景技术临床医生可对患有持续性或复发性菌血症的患者采用抑制性抗菌治疗。但是，具有良好敏感性的细菌可能会表现出抗菌耐受性，其中细菌无法增殖，但可以在高浓度的抗生素中存活。抗菌素耐受表型可能会阻止通过长时间接触抗菌素而防止菌血症复发的努力，并且可能在患者接受积极治疗时导致突破性菌血症。在这里，我们介绍了一个病人案例，该案例由适当剂量的抑菌治疗设定的多年中突破性金黄色葡萄球菌菌血症多次发作组成，并描述了在治疗过程中发生的机体突变。

著录项

期刊名称 Open Forum Infectious Diseases
作者
Andrew Berti; Jeremy Schroeder; Aaron Rottier; Sue McCrone; Jade Wang; Warren Rose;
展开▼
作者单位

展开▼
年(卷),期 2017(4),Suppl 1
年度 2017
页码 S14
总页数 1
原文格式 PDF
正文语种
中图分类病毒传染病;
关键词

相似文献

外文文献
中文文献
专利

1. Daptomycin in combination with other antibiotics for the treatment of complicated Methicillin-resistant staphylococcus aureus bacteremia [J] . DhandA., SakoulasG. Clinical therapeutics . 2014,第10期

机译：达托霉素联合其他抗生素治疗耐甲氧西林的复杂金黄色葡萄球菌菌血症
2. Comparing the Outcomes of Ceftaroline Plus Vancomycin or Daptomycin Combination Therapy Versus Monotherapy in Adults with Complicated and Prolonged Methicillin-Resistant Staphylococcus Aureus Bacteremia Initially Treated with Supplemental Ceftaroline [J] . Progress in Artificial Intelligence . 2020,第1期

机译：比较Ceftaroline Plus vancomycin或Daptomycin组合治疗对成年人的单一疗法的复杂和延长的甲氧西林耐药葡萄球菌血糖药物最初用补充头孢尔碱治疗
3. Comparing the Outcomes of Ceftaroline Plus Vancomycin or Daptomycin Combination Therapy Versus Monotherapy in Adults with Complicated and Prolonged Methicillin-Resistant Staphylococcus Aureus Bacteremia Initially Treated with Supplemental Ceftaroline [J] . Omar Ahmad, Timothy N. Crawford, Thein Myint Infectious Diseases and Therapy . 2020,第1期

机译：比较Ceftaroline Plus vancomycin或Daptomycin组合治疗与成人单药治疗复杂和延长的甲氧西林耐金黄色葡萄球菌菌血症的结果，最初用辅作治疗
4. Investigation into the potential of sub-lethal photodynamic antimicrobial chemotherapy (PACT) to reduce susceptibility of meticillin-resistant Staphylococcus aureus (MRSA) to antibiotics [C] . C. M. Cassidy, R. F. Donnelly, M. M. Tunney World congress of the International Photodynamic Association . 2009

机译：研究亚致死性光动力抗菌化学疗法（PACT）降低耐甲氧西林金黄色葡萄球菌（MRSA）对抗生素的敏感性
5. Empiric therapy and mortality among patients with Staphylococcus aureus bacteremia. [D] . Schweizer, Marin L. 2009

机译：金黄色葡萄球菌菌血症患者的经验治疗和死亡率。
6. 2403. Comparison of Daptomycin Combination Therapy With Ceftaroline or Oxacillin Against Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates Causing Persistent Bacteremia [O] . Jeannette Bouchard, Chelsea Jones, Ellen Kline, -1

机译：2403.达托霉素与头孢洛林或奥沙西林联合治疗抗耐甲氧西林金黄色葡萄球菌（MRSA）菌株的比较引起持久性细菌血症
7. 2403. Comparison of Daptomycin Combination Therapy With Ceftaroline or Oxacillin Against Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates Causing Persistent Bacteremia [O] . Jeannette Bouchard, Chelsea Jones, Ellen Kline, 2018

机译：2403.与甲氧丙氨素或牛奶蛋白对甲氧西林葡萄球菌（MRSA）分离株导致持久性菌血症的达氨霉素组合疗法的比较

Evolution of Antibiotic Tolerance During Oxacillin Daptomycin and Dalbavancin Therapy Results in Breakthrough Staphylococcus aureus Bacteremias

摘要

著录项

相似文献

相关主题

期刊订阅