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Association of deposition of tau and amyloid‐β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients

机译：在认知正常的老年人和阿尔茨海默氏病谱患者中tau蛋白和淀粉样β蛋白的沉积与结构连接性改变的关联

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IntroductionAlzheimer's disease (AD) is characterized by accumulation of extracellular amyloid‐β and intracellular tau neurofibrillary tangles. The recent advent of tau positron emission tomography (PET) has enabled in vivo assessment of tau pathology. The aim of this study was to explore whether tau deposition influences the structural connectivity in amyloid‐negative and amyloid‐positive groups, and further explore the difference between the groups.

机译：简介阿尔茨海默氏病（AD）的特征是细胞外淀粉样β和细胞内tau神经原纤维缠结的积累。 tau正电子发射断层扫描（PET）的最新出现使得能够对tau病理进行体内评估。这项研究的目的是探讨tau沉积是否影响淀粉样蛋白阴性和淀粉样蛋白阳性组的结构连接性，并进一步探讨这些组之间的差异。

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期刊名称 Brain and Behavior
作者
Yoko Shigemoto; Daichi Sone; Norihide Maikusa; Nobuyuki Okamura; Shozo Furumoto; Yukitsuka Kudo; Masayo Ogawa; Harumasa Takano; Yuma Yokoi; Masuhiro Sakata; Tadashi Tsukamoto; Koichi Kato; Noriko Sato; Hiroshi Matsuda;
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年(卷),期 2018(8),12
年度 2018
页码 e01145
总页数 11
原文格式 PDF
正文语种
中图分类医学行为学;
关键词
Alzheimer’s disease diffusion tensor imaging structural network tau PET;

机译：阿尔茨海默氏病;张量张量成像;结构网络;tau PET;

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专利

1. Association of deposition of tau and amyloid‐β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients [J] . Yoko Shigemoto, Daichi Sone, Norihide Maikusa, Brain and Behavior . 2018,第12期

机译：在认知正常的成年人和阿尔茨海默氏病谱患者中，tau蛋白和淀粉样β蛋白的沉积与结构连接性改变的关联
2. ASSOCIATION OF TAU AND AMYLOID-β PROTEINS TO STRUCTURAL CONNECTIVITY CHANGES IN COGNITIVELY HEALTHY ELDERLY AND EARLY ALZHEIMER’S DISEASE [J] . Yoko Shigemoto, Daichi Sone, Masayo Ogawa, Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2018,第7期

机译：Tau和淀粉样蛋白-β蛋白与认知健康老年人和早期阿尔茨海默病的结构连通性变化
3. VARIABILITY IN PDMN CONNECTIVITY AND RELATIVE HUBNESS IN COGNITIVELY NORMAL INDIVIDUALS PREDICT AMYLOID AND TAU DEPOSITION PATTERNS IN TYPICAL ALZHEIMER’S DISEASE [J] . Hugo Botha, Jonathan Graff-Radford, Val J. Lowe, Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2018,第7期

机译：Cognitive Normants中的PDMN连接和相对毂的可变性预测典型的阿尔茨海默病中的淀粉样蛋白和TAU沉积模式
4. Quantitative Analysis of Amyloid Beta Deposition in the Brain of Alzheimer's Disease Patients Using PET and ~()11CBF-227 and ~(18)FFACT [C] . M. Tashiro, N. Okamura, S. Watanuki, Asia Pacific conference on biomechanics;International conference on biomedical engineering;ICBME;APBiomech;World congress of biomechanics;WCB 2010 . 2011

机译：使用PET和〜（）11C BF-227和〜（18）F FACT定量分析阿尔茨海默病患者大脑中淀粉样蛋白的沉积
5. Targeted siRNA-mediated down-regulation of the expression of amyloid precursor and tau proteins implicated in Alzheimer's disease in neuroblastoma cell lines. [D] . Patel, Krishna. 2016

机译：靶向siRNA介导的神经母细胞瘤细胞系中与阿尔茨海默氏病有关的淀粉样蛋白前体和tau蛋白表达的下调。
6. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimers disease [O] . Anne M Fagan, Mark A Mintun, Aarti R Shah, 2009

机译：认知正常个体中脑脊液tau和ptau181随着皮质淀粉样蛋白沉积的增加而增加：对阿尔茨海默氏病未来临床试验的意义
7. Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients [O] . Yoko Shigemoto, Daichi Sone, Norihide Maikusa, 2018

机译：TAU和淀粉样蛋白-β蛋白的沉积与认知普通成人和阿尔茨海默病谱患者的结构连通性变化

Association of deposition of tau and amyloid‐β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients

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