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Spatial learning and long‐term memory impairments in RasGrf1 KO Pttg1 KO and double KO mice

机译：RasGrf1 KOPttg1 KO和double KO小鼠的空间学习和长期记忆障碍

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BackgroundRasGrf1 is a guanine‐nucleotide releasing factor that enhances Ras activity. Human PTTG1 is an oncoprotein found in pituitary tumors and later identified as securin, a protein isolated from yeast with a reported role in chromosome separation. It has been suggested that RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and their physiological response. At memory formation level, there are contradictory data regarding the role of RasGrf1, while Pttg1 has not been previously studied. Both proteins are expressed in the mammalian hippocampus, which is one of the key brain areas for spatial learning and memory.

机译：背景RasGrf1是鸟嘌呤核苷酸释放因子，可增强Ras活性。人PTTG1是一种在垂体肿瘤中发现的癌蛋白，后来被鉴定为securin，这是一种从酵母中分离出的蛋白，据报道在染色体分离中起作用。有人提出RasGrf1是调节Pttg1表达和控制β细胞发育及其生理反应的信号转导通路的重要上游成分。在记忆形成水平上，关于RasGrf1的作用有相互矛盾的数据，而Pttg1以前没有研究过。两种蛋白都在哺乳动物海马中表达，这是空间学习和记忆的关键大脑区域之一。

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期刊名称 Brain and Behavior
作者
Lara Manyes; Sarah Holst; Manuel Lozano; Eugenio Santos; Alberto Fernandez‐Medarde;
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作者单位

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年(卷),期 2018(8),11
年度 2018
页码 e01089
总页数 10
原文格式 PDF
正文语种
中图分类医学行为学;
关键词
Barnes maze memory PCA Pttg1 RasGrf1 spatial learning;

机译：巴恩斯迷宫;记忆;PCA;Pttg1;RasGrf1;空间学习;

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1. Spatial learning and long‐term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice [J] . Lara Manyes, Sarah Holst, Manuel Lozano, Brain and Behavior . 2018,第11期

机译：Rasgrf1 Ko，Pttg1 Ko和双KO小鼠的空间学习和长期记忆障碍
2. Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments [J] . Guillermo Coronas-Samano, Keeley L. Baker, Winston J. T. Tan, Frontiers in Aging Neuroscience . 2016,第3期

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3. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory [J] . Reinhard Sarah M., Rais Maham, Afroz Sonia, Neurobiology of learning and memory . 2019,第期

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4. Ab initio molecular dynamics simulations on high-temperature reaction rates of reactions KO+CO==K+CO_2, KO+C==K+CO, and K_2O+CO_2==K_2CO_3 [C] . Dong Yanhua, Li Xiaojia International Conference on Advanced Material and Manufacturing Science . 2014

机译：AB Initio分子动力学模拟反应高温反应速率KO + CO == K + CO_2，KO + C == k + CO，K_2O + CO_2 == K_2CO_3
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6. Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimers Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments [O] . Guillermo Coronas-Samano, Keeley L. Baker, Winston J. T. Tan, 2016

机译：Fus1 KO小鼠作为氧化应激介导的偶发性阿尔茨海默氏病的模型：昼夜节律紊乱和长期的空间和嗅觉记忆障碍。
7. Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice [O] . Lara Manyes, Sarah Holst, Manuel Lozano, 2018

机译：Rasgrf1 Ko，Pttg1 Ko和双KO小鼠的空间学习和长期记忆障碍

Spatial learning and long‐term memory impairments in RasGrf1 KO Pttg1 KO and double KO mice

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