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首页> 美国卫生研究院文献>Social Cognitive and Affective Neuroscience >Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth
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Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth

机译：不好看：抑郁青年情绪调节受损的神经相关

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The cognitive regulation of emotion is impaired in major depressive disorder and has been linked to an imbalance of pre-frontal–subcortical brain activity. Despite suggestions that this relationship represents a neurodevelopmental marker of depression, few studies have examined the neural correlates of emotion regulation in depressed youth. We combined a ‘cognitive reappraisal’ paradigm with functional magnetic resonance imaging to study the neural correlates of emotional regulation in a large sample of non-medicated depressed adolescents and young adults (n = 53) and healthy controls (n = 64). As compared with healthy controls, young people with depression were less able to reduce negative affect during reappraisal, which corresponded to blunted modulation of amygdala activity. While in healthy individuals amygdala activation was modulated by age, no such relationship was observed in depressed individuals. Heightened activation of the ventromedial pre-frontal cortex (vmPFC) and reduced activation of the dorsal midline cortex was also found for the depressed group. Overall, these findings suggest that brain systems that support cognitive reappraisal are functionally altered in youth depression. We argue that excessive engagement of the vmPFC in particular, may be central to understanding how the process of putting a ‘positive spin’ on negative emotional material may be altered in depressed youth.
机译：情绪的认知调节在重度抑郁症中受损，并且与前额叶皮层下大脑活动的失衡有关。尽管有人建议这种关系代表抑郁症的神经发育标志，但很少有研究检查抑郁症青年情绪调节的神经相关性。我们将“认知再评估”范例与功能性磁共振成像相结合，以研究大量非药物治疗的抑郁青少年和年轻成年人（n = 53）和健康对照（n = 64）中情绪调节的神经相关性。与健康对照组相比，抑郁症的年轻人在重新评估过程中减少负面影响的能力较弱，这与杏仁核活动的调节减弱有关。在健康个体中，杏仁核的激活受年龄的调节，而在抑郁者中则未观察到这种关系。抑郁组的腹侧前额叶皮层（vmPFC）激活增强，背中线皮层激活降低。总体而言，这些发现表明，在青年抑郁症中，支持认知重新评估的大脑系统功能发生了变化。我们认为，尤其是vmPFC的过度投入可能是理解抑郁的年轻人如何改变对消极情绪物质进行“正向旋转”的过程的中心。

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