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Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease

机译：唾液外泌体PSMA7：炎性肠病的有前途的生物标志物

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Inflammatory bowel disease (IBD) is an intestinal immune-dysfunctional disease worldwide whose prevalence increasing in Asia including China. It is a chronic disease of the gastrointestinal tract with unknown cause. Exosomes are small vesicles in various body fluids. They have diameters of 40–120 nm, and one of their functions is long-distance transfer of various substances. In this study, we investigated the contents of salivary exosomes in patients with IBD and in healthy controls to explore a new biomarker in patients with IBD. In this study, whole saliva was obtained from patients with IBD (ulcerative colitis (UC), n = 37; Crohn’s disease (CD), n = 11) and apparently healthy individuals (HC, n = 10). Salivary exosomes were extracted from samples, and the proteins within the exosomes were identified by liquid chromatograph-mass spectrometer (LC-MS/MS). The results showed that more than 2000 proteins were detected in salivary exosomes from patients with IBD. Through gene ontology analysis, we found that proteasome subunit alpha type 7 (PSMA7) showed especially marked differences between patients with IBD and the healthy controls, in that its expression level was much higher in the CD and UC groups. This exosomal protein is related to proteasome activity and inflammatory responses. So we conclude that in this research, salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with IBD. It can be a very promising biomarker to release the patients from the pain of colonoscopy.Electronic supplementary materialThe online version of this article (doi:10.1007/s13238-017-0413-7) contains supplementary material, which is available to authorized users.
机译：炎症性肠病（IBD）是一种在全球范围内引起肠道免疫功能障碍的疾病，在包括中国在内的亚洲，其患病率呈上升趋势。它是胃肠道慢性疾病，病因不明。外泌体是各种体液中的小囊泡。它们的直径为40-120 nm，其功能之一是各种物质的长距离转移。在这项研究中，我们调查了IBD患者和健康对照者唾液外泌体的含量，以探索IBD患者的新生物标志物。在这项研究中，全部唾液来自IBD（溃疡性结肠炎（UC），n = 37;克罗恩病（CD），n = 11）和明显健康的个体（HC，n = 10）。从样品中提取唾液外泌体，并通过液相色谱-质谱仪（LC-MS / MS）鉴定外泌体内的蛋白质。结果表明，在IBD患者的唾液外泌体中检测到2000多种蛋白质。通过基因本体分析，我们发现蛋白酶体亚基α7型（PSMA7）在IBD患者和健康对照之间表现出特别明显的差异，因为CD和UC组中其表达水平更高。该外泌体蛋白与蛋白酶体活性和炎症反应有关。因此，我们得出结论，在这项研究中，IBD患者的唾液外泌体中唾液外泌体PSMA7的含量很高。电子释放补充材料本文的在线版本（doi：10.1007 / s13238-017-0413-7）包含补充材料，授权用户可以使用。

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