A summary of the Japan septic disseminated intravascular coagulation study

机译：日本化脓性弥散性血管内凝血研究综述

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Over the past few decades, the large, international, randomized controlled trials of anticoagulant therapies for patients with sepsis have not yielded any improvement in mortality rates. However, in Japan, anticoagulant therapies are administered for sepsis patients with disseminated intravascular coagulation (DIC), but not for sepsis patients without DIC. Furthermore, epidemiological data regarding sepsis in Japan are scarce. Therefore, a nationwide multicenter retrospective observational study, the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study, was undertaken. The JSEPTIC DIC study enrolled 42 intensive care units and included 3,195 patients with sepsis. The results of the JSEPTIC DIC study indicated the following: (i) anticoagulant therapy may be effective in sepsis‐induced DIC patients at high risk for death, (ii) recombinant human soluble thrombomodulin administration and antithrombin supplementation are associated with survival benefits in patients with sepsis‐induced DIC.

机译：在过去的几十年中，针对脓毒症患者进行抗凝治疗的大型国际随机对照试验并未使死亡率得到任何改善。但是，在日本，对具有弥散性血管内凝血（DIC）的脓毒症患者进行抗凝治疗，而对没有DIC的脓毒症患者不给予抗凝治疗。此外，关于日本败血症的流行病学数据很少。因此，进行了一项全国性的多中心回顾性观察性研究，即日本败血症性弥散性血管内凝血研究（JSEPTIC DIC）。 JSEPTIC DIC研究招募了42个重症监护病房，包括3,195名败血症患者。 JSEPTIC DIC研究的结果表明：（i）抗凝治疗可能对败血症诱发的DIC高死亡风险患者有效；（ii）重组人可溶性凝血调节蛋白的给药和抗凝血酶的补充与罹患糖尿病的患者的生存获益相关败血症诱导的DIC。

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期刊名称 Acute Medicine Surgery
作者
Mineji Hayakawa; Kota Ono;
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作者单位

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年(卷),期 2018(5),2
年度 2018
页码 123–128
总页数 6
原文格式 PDF
正文语种
中图分类
关键词
coagulopathy sepsis/multiple organ failure;

机译：凝血病;败血症/多器官衰竭;

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专利

1. A summary of the Japan septic disseminated intravascular coagulation study [J] . Mineji Hayakawa, Kota Ono Acute Medicine & Surgery . 2018,第2期

机译：日本化脓性弥散性血管内凝血研究综述
2. The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine [J] . Koami Hiroyuki, Sakamoto Yuichiro, Sakurai Ryota, Medicine. . 2016,第31期

机译：由日本急性医学协会的评分系统诊断为化脓和创伤引起的弥散性血管内凝血的血栓弹力测定差异
3. The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine [J] . Koami Hiroyuki, Sakamoto Yuichiro, Sakurai Ryota, Medicine. . 2016,第31期

机译：从日本急性医学协会诊断患者诱导症状和创伤诱导血管内凝血的血管内血管凝固
4. Disseminated Intravascular Coagulation: Concepts, Challenges and Conundrums [C] . American College of Veterinary Internal Medicine Forum Conference . 2019

机译：传播血管内凝血：概念，挑战和难题
5. Evaluation of point of care tests for the diagnosis of disseminated intravascular coagulation in dogs [D] . Bateman, Shane William 1998

机译：评估护理点测试对犬弥散性血管内凝血的诊断
6. The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine [O] . Hiroyuki Koami, Yuichiro Sakamoto, Ryota Sakurai, -1

机译：由日本急性医学协会的评分系统诊断为脓毒症和创伤引起的弥散性血管内凝血的血栓弹力测定差异
7. The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine [O] . Hiroyuki Koami, Yuichiro Sakamoto, Ryota Sakurai, 2016

机译：抗化脓性和创伤诱导促进急性医学分析诊断的血管内血管凝血的血管内血管凝固

A summary of the Japan septic disseminated intravascular coagulation study

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