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Measurement of amyloid formation by turbidity assay—seeing through the cloud

机译：通过浊度分析测量淀粉样蛋白的形成-透过云看

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摘要

Detection of amyloid growth is commonly carried out by measurement of solution turbidity, a low-cost assay procedure based on the intrinsic light scattering properties of the protein aggregate. Here, we review the biophysical chemistry associated with the turbidimetric assay methodology, exploring the reviewed literature using a series of pedagogical kinetic simulations. In turn, these simulations are used to interrogate the literature concerned with in vitro drug screening and the assessment of amyloid aggregation mechanisms.

机译：淀粉样蛋白生长的检测通常通过测量溶液浊度来进行，这是一种基于蛋白质聚集体固有光散射特性的低成本测定方法。在这里，我们回顾了与浊度测定法相关的生物物理化学，并使用一系列的教学动力学模拟来探索回顾的文献。反过来，这些模拟被用来询问有关体外药物筛选和淀粉样蛋白聚集机制评估的文献。

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期刊名称 Biophysical Reviews
作者
Ran Zhao; Masatomo So; Hendrik Maat; Nicholas J. Ray; Fumio Arisaka; Yuji Goto; John A. Carver; Damien Hall;
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作者单位

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年(卷),期 2016(8),4
年度 2016
页码 445–471
总页数 27
原文格式 PDF
正文语种
中图分类生物学;
关键词
Amyloid biophysics Turbidimetric method Amyloid aggregation kinetics Data reduction Nonlinear signal response;

机译：淀粉样生物物理;比浊法;淀粉样聚集动力学;数据约简;非线性信号响应;

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专利

1. Measurement of amyloid formation by turbidity assay—seeing through the cloud [J] . Ran Zhao, Masatomo So, Hendrik Maat, Biophysical reviews . 2016,第4期

机译：通过浊度分析测量淀粉样蛋白的形成-透过云看
2. Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements [J] . UlfAndreasson, JuliaKuhlmann, JosefPannee, Clinical chemistry and laboratory medicine: CCLM . 2018,第12期

机译：经认证参考材料的交换性，用于人脑脊髓液中β-淀粉样蛋白1-42测定的标准化：TAU和β-淀粉样蛋白1-40测量的课程
3. A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation [J] . Kudva YC., Butler PC., Eberhardt NL., The Biochemical Journal . 1998,第Pta3期

机译：人胰岛淀粉样多肽淀粉样蛋白生成的新方法和胰岛素分泌囊泡肽对淀粉样蛋白形成的影响
4. Assay for the Simultaneous Measurement of Multiple Amyloid Beta Isoforms [C] . Kwasi G. Mawuenyega, Randall J. Bateman American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：用于同时测量多个淀粉样蛋白β同种型的测定
5. Aerosol-Cloud-Precipitation Interaction in Ultraclean Layers and Optically Thin Veil Cloud System in the Stratocumulus to Cumulus Transition: Remote Sensing Measurements and Cloud Resolving Model Results [D] . O, Kuan-Ting. 2019

机译：超薄层气溶云降水相互作用和划分为巨大转型的光学薄面纱云系统：遥感测量和云解析模型结果
6. The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design [O] . Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, 2012

机译：三苯基甲烷染料亮蓝G仅在抑制人淀粉样蛋白形成淀粉样蛋白或分解淀粉样蛋白淀粉样蛋白原纤维方面具有中等效力，但会干扰淀粉样蛋白的测定。对抑制剂设计的影响
7. Measurement of amyloid formation by turbidity assay—seeing through the cloud [O] . Ran Zhao, Masatomo So, Hendrik Maat, 2016

机译：通过浊度分析测量淀粉样蛋白的形成-透过云看

Measurement of amyloid formation by turbidity assay—seeing through the cloud

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