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首页> 美国卫生研究院文献>Journal of Applied Clinical Medical Physics >A benchmarking method to evaluate the accuracy of a commercial proton monte carlo pencil beam scanning treatment planning system
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A benchmarking method to evaluate the accuracy of a commercial proton monte carlo pencil beam scanning treatment planning system

机译：评估商用质子蒙特卡洛铅笔束扫描治疗计划系统准确性的基准测试方法

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AcurosPT is a Monte Carlo algorithm in the Eclipse 13.7 treatment planning system, which is designed to provide rapid and accurate dose calculations for proton therapy. Computational run‐time in minimized by simplifying or eliminating less significant physics processes. In this article, the accuracy of AcurosPT was benchmarked against both measurement and an independent MC calculation, TOPAS. Such a method can be applied to any new MC calculation for the detection of potential inaccuracies. To validate multiple Coulomb scattering (MCS) which affects primary beam broadening, single spot profiles in a Solidwater® phantom were compared for beams of five selected proton energies between AcurosPT, measurement and TOPAS. The spot Gaussian sigma in AcurosPT was found to increase faster with depth than both measurement and TOPAS, suggesting that the MCS algorithm in AcurosPT overestimates the scattering effect. To validate AcurosPT modeling of the halo component beyond primary beam broadening, field size factors (FSF) were compared for multi‐spot profiles measured in a water phantom. The FSF for small field sizes were found to disagree with measurement, with the disagreement increasing with depth. Conversely, TOPAS simulations of the same style="fixed-case">FSF consistently agreed with measurement to within 1.5%. The disagreement in absolute dose between Acuros style="fixed-case">PT and measurement was smaller than 2% at the mid‐range depth of multi‐energy beams. While Acuros style="fixed-case">PT calculates acceptable dose distributions for typical clinical beams, users are cautioned of potentially larger errors at distal depths due to overestimated style="fixed-case">MCS and halo implementation.
机译：AcurosPT是Eclipse 13.7治疗计划系统中的蒙特卡洛算法，旨在为质子治疗提供快速准确的剂量计算。通过简化或消除不太重要的物理过程，将计算运行时间最小化。在本文中，将AcurosPT的准确性与测量和独立的MC计算TOPAS进行了基准测试。可以将这种方法应用于任何新的MC计算以检测潜在的不准确性。为了验证影响一次光束展宽的多重库仑散射（MCS），比较了在AcurosPT，测量和TOPAS之间选择的五个质子能量的光束在Solidwater ®体模中的单点分布。发现AcurosPT中的高斯σ点随深度的增加比测量和TOPAS都快，这表明AcurosPT中的MCS算法高估了散射效果。为了验证超越主要光束展宽的光晕分量的AcurosPT建模，比较了水体模型中测量的多点剖面的场大小因子（FSF）。发现小场的FSF与测量不一致，并且随着深度的增加而增加。相反地​​，相同 style =“ fixed-case”> FSF 的TOPAS模拟一致地将测量结果控制在1.5％以内。在多能束的中程深度，Acuros style =“ fixed-case”> PT 与测量值之间的绝对剂量差异小于2％。尽管Acuros style =“ fixed-case”> PT 为典型的临床射线计算可接受的剂量分布，但要告诫用户，由于高估了 style =“ fixed-case”> MCS，在远端深度可能存在较大的误差和光晕实现。

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