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首页> 美国卫生研究院文献>Database: The Journal of Biological Databases and Curation >PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae
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PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae

机译：PhosphoGRID：数据库中经过实验验证的来自萌芽酵母酿酒酵母的体内蛋白质磷酸化位点

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摘要

Protein phosphorylation plays a central role in cellular regulation. Recent proteomics strategies for identifying phosphopeptides have been developed using the model organism Saccharomyces cerevisiae, and consequently, when combined with studies of individual gene products, the number of reported specific phosphorylation sites for this organism has expanded enormously. In order to systematically document and integrate these various data types, we have developed a database of experimentally verified in vivo phosphorylation sites curated from the S. cerevisiae primary literature. PhosphoGRID () records the positions of over 5000 specific phosphorylated residues on 1495 gene products. Nearly 900 phosphorylated residues are reported from detailed studies of individual proteins; these in vivo phosphorylation sites are documented by a hierarchy of experimental evidence codes. Where available for specific sites, we have also noted the relevant protein kinases and/or phosphatases, the specific condition(s) under which phosphorylation occurs, and the effect(s) that phosphorylation has on protein function. The unique features of PhosphoGRID that assign both function and specific physiological conditions to each phosphorylated residue will provide a valuable benchmark for proteome-level studies and will facilitate bioinformatic analysis of cellular signal transduction networks.>Database URL:
机译：蛋白质磷酸化在细胞调节中起着核心作用。使用模型生物酿酒酵母已经开发了用于鉴定磷酸肽的最新蛋白质组学策略，因此，当与单个基因产物的研究相结合时，针对该生物报道的特定磷酸化位点的数量已大大增加。为了系统地记录和整合这些各种数据类型，我们开发了一个数据库，该数据库从酿酒酵母的原始文献中筛选出经过实验验证的体内磷酸化位点。 PhosphoGRID（）记录了1495个基因产物上5000多个特定磷酸化残基的位置。单个蛋白质的详细研究报告了将近900个磷酸化残基。这些体内磷酸化位点由实验证据代码的层次结构记录。在可用于特定位点的地方，我们还注意到了相关的蛋白激酶和/或磷酸酶，发生磷酸化的具体条件以及磷酸化对蛋白质功能的影响。 PhosphoGRID的独特功能可为每个磷酸化残基赋予功能和特定的生理条件，这将为蛋白质组学水平的研究提供有价值的基准，并将促进细胞信号转导网络的生物信息学分析。>数据库URL：

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