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首页> 美国卫生研究院文献>EJNMMI Research >The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson’s disease or clinically uncertain parkinsonism: a systematic review
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The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson’s disease or clinically uncertain parkinsonism: a systematic review

机译：多巴胺转运蛋白SPECT成像对帕金森病或临床不确定性帕金森病患者黑纹状体细胞丢失的诊断准确性：系统评价

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In specialized movement disorder centers, Parkinson’s disease (PD) is wrongly diagnosed in 6 to 25% of cases. To improve the accuracy of the clinical diagnosis, it is necessary to have a reliable and practical reference standard. Dopamine transporter single-photon emission computed tomography (DAT SPECT) imaging might have the potential (high diagnostic accuracy and practical to use) to act as reference standard in detecting nigrostriatal cell loss in patients with (early stage) parkinsonism. We performed a systematic review to evaluate if DAT SPECT imaging can be used as such. Relevant studies were searched in the MEDLINE and EMBASE databases. Studies were selected when they met the following criteria: (1) all patients were adults with a clinical diagnosis of PD or clinically uncertain parkinsonism and (2) the study reported original data. In addition, studies needed to fulfill one of the two following criteria: (1) patients underwent at least one DAT SPECT and had a neuropathological confirmed diagnosis and (2) patients underwent at least two DAT SPECT scans, performed at least 2 years apart. The search identified 1,649 articles. Eight studies fulfilled our selection criteria and were included in this review. There was only one study including patients with diagnostic uncertainty. Sensitivity and specificity of DAT SPECT imaging to detect nigrostriatal cell loss were 98%. The other studies included patients with a diagnosis of PD in whom there was no uncertainty. In these studies, sensitivity was 100%. Our systematic review indicates that DAT SPECT imaging seems to be accurate to detect nigrostriatal cell loss in patients with parkinsonism.Electronic supplementary materialThe online version of this article (doi:10.1186/s13550-015-0087-1) contains supplementary material, which is available to authorized users.
机译：在专门的运动障碍中心，帕金森氏病（PD）被误诊为6％至25％的病例。为了提高临床诊断的准确性，有必要建立一个可靠实用的参考标准。多巴胺转运蛋白单光子发射计算机断层扫描（DAT SPECT）成像可能具有（较高的诊断准确度和实用性）作为检测帕金森病（早期）患者黑质纹状体细胞丢失的参考标准。我们进行了系统的评估，以评估DAT SPECT成像是否可以原样使用。在MEDLINE和EMBASE数据库中搜索了相关研究。选择符合以下标准的研究：（1）所有患者均为成人，临床诊断为PD或临床上不确定的帕金森氏症；（2）研究报告了原始数据。此外，研究还需要满足以下两个标准之一：（1）患者至少进行了一次DAT SPECT并具有神经病理学确诊结果；（2）患者接受了至少两次DAT SPECT扫描，间隔至少2年。搜索确定了1,649篇文章。八项研究符合我们的选择标准，已包括在本评价中。只有一项研究包括诊断不确定的患者。 DAT SPECT成像检测黑纹状体细胞丢失的敏感性和特异性为98％。其他研究包括诊断为PD的患者，没有不确定性。在这些研究中，敏感性为100％。我们的系统评价表明，DAT SPECT成像似乎可以准确检测帕金森病患者的黑质纹状体细胞丢失。电子补充材料本文的在线版本（doi：10.1186 / s13550-015-0087-1）包含补充材料，可以通过以下途径获得给授权用户。

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