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首页> 美国卫生研究院文献>Physiological Reports >Efficient training protocol for rapid learning of the two‐alternative forced‐choice visual stimulus detection task
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Efficient training protocol for rapid learning of the two‐alternative forced‐choice visual stimulus detection task

机译：快速培训两种备选强迫选择视觉刺激检测任务的有效培训协议

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摘要

The potential of genetically engineered rodent models has accelerated demand for training procedures of behavioral tasks. Such training is generally time consuming and often shows large variability in learning speed between animals. To overcome these problems, we developed an efficient and stable training system for the two‐alternative forced‐choice (2AFC) visual stimulus detection task for freely behaving rodents. To facilitate the task learning, we introduced a spout‐lever as the operandum and a three‐step training program with four ingenuities: (1) a salient stimulus to draw passive attention, (2) a reward‐guaranteed trial to keep motivation, (3) a behavior‐corrective trial, and (4) switching from a reward‐guaranteed trial to a nonguaranteed one to correct behavioral patterns. Our new training system realizes 1‐week completion of the whole learning process, during which all rats were able to learn effortlessly the association between (1) lever‐manipulation and reward and (2) visual stimulus and reward in a step‐by‐step manner. Thus, our new system provides an effective and stable training method for the 2AFC visual stimulus detection task. This method should help accelerate the move toward research bridging the visual functions measured in behavioral tasks and the contributing specific neuronsetworks that are genetically manipulated or optically controlled.
机译：基因工程啮齿动物模型的潜力加速了对行为任务训练程序的需求。这种训练通常很耗时，并且经常在动物之间显示出很大的学习速度差异。为了克服这些问题，我们为自由活动的啮齿动物开发了两种替代强迫选择（2AFC）视觉刺激检测任务的有效且稳定的训练系统。为了促进任务学习，我们引入了喷杆作为操作员，并引入了三步训练程序，其中包括四项独创性：（1）激发被动注意力的显着刺激;（2）保持动机的奖励保证试验;（ 3）纠正行为的试验，以及（4）从奖励保证的试验切换到无保证的试验以纠正行为模式。我们的新训练系统实现了整个学习过程的1周完成，在此过程中，所有大鼠都能轻松学习（1）操纵和奖励与（2）视觉刺激和奖励之间的关联方式。因此，我们的新系统为2AFC视觉刺激检测任务提供了有效而稳定的训练方法。这种方法应有助于加速研究工作，以桥接行为任务中测得的视觉功能和通过基因操作或光学控制的特定神经元/网络。

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