Replication of avian influenza viruses in equine tracheal epithelium but not in horses

机译：禽流感病毒在马气管上皮中复制但不在马中复制

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摘要

We evaluated a hypothesis that horses are susceptible to avian influenza viruses by in vitro testing, using explanted equine tracheal epithelial cultures, and in vivo testing by aerosol inoculation of ponies. Results showed that several subtypes of avian influenza viruses detectably replicated in vitro. Three viruses with high in vitro replication competence were administered to ponies. None of the three demonstrably replicated or caused disease signs in ponies. While these results do not exhaustively test our hypothesis, they do highlight that the tracheal explant culture system is a poor predictor of in vivo infectivity.

机译：我们评估了一个假说，即通过体外测试，使用外植的马气管上皮培养物以及通过气溶胶接种小马进行体内测试，对马容易感染禽流感病毒。结果表明，在体外可检测到几种亚型禽流感病毒复制。将三种具有高体外复制能力的病毒施用于小马。这三个小动物均无明显复制或引起小马疾病迹象。尽管这些结果并未详尽地检验我们的假设，但它们确实突出了气管外植体培养系统对体内感染性的不良预测。

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期刊名称 Influenza and Other Respiratory Viruses
作者
Thomas M. Chambers; Udeni B. R. Balasuriya; Stephanie E. Reedy; Ashish Tiwari;
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作者单位

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年(卷),期 2013(7),Suppl Suppl 4
年度 2013
页码 90–93
总页数 4
原文格式 PDF
正文语种
中图分类病毒传染病;人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
Avian influenza equine influenza host range interspecies transmission organ culture;

机译：禽流感;马流感;宿主范围;种间传播;器官培养;

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专利

1. Replication of avian influenza viruses in equine tracheal epithelium but not in horses [J] . ChambersT.M., BalasuriyaU.B.R., ReedyS.E., Influenza and other respiratory viruses. . 2013,第Supplas4期

机译：禽流感病毒在马气管上皮中复制，但不在马中复制
2. Replication of avian influenza viruses in equine tracheal epithelium but not in horses [J] . Stephanie E. Reedy, Thomas M. Chambers, Udeni B. R. Balasuriya Influenza and other respiratory viruses. . 2013,第s4期

机译：禽流感病毒在马气管上皮中复制，但不在马中复制
3. Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses [J] . Debby van Riel, Michael A. den Bakker, Lonneke M.E. Leijten, American Journal of Pathology . 2010,第4期

机译：季节性和大流行的人类流感病毒比禽流感病毒对人上呼吸道上皮的附着更好
4. Review of Interspecies Transmission of Influenza A Viruses: Implications for the Equine Population [C] . Gabriele A. Landolt Annual Convention of the American Association of Equine Practitioners . 2006

机译：综述流感传播流感病毒：为马匹人口的影响
5. Surveillance of equine influenza virus and cause specific morbidity rate in young horses in Ontario. [D] . Diaz Mendez, Andres. 2006

机译：监视马流感病毒并导致安大略省幼马的特定发病率。
6. Replication and Adaptive Mutations of Low Pathogenic Avian Influenza Viruses in Tracheal Organ Cultures of Different Avian Species [O] . Henning Petersen, Mikhail Matrosovich, Stephan Pleschka, -1

机译：低致病性禽流感病毒在不同鸟类的气管器官培养的复制和适应性突变
7. Replication and adaptive mutations of low pathogenic avian influenza viruses in tracheal organ cultures of different avian species. [O] . Henning Petersen, Mikhail Matrosovich, Stephan Pleschka, 2012

机译：低致病性禽流感病毒在不同禽类气管器官培养物中的复制和适应性突变。
8. OSHA Guidance Update on Protecting Employees from Avian Flu (Avian Influenza) Viruses [R] . 2006

机译：OsHa关于保护员工免受禽流感（禽流感）病毒侵害的指导性更新

Replication of avian influenza viruses in equine tracheal epithelium but not in horses

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