MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors

机译：乳腺癌中MMP-9和MMP-2明胶酶以及TIMP-1和TIMP-2抑制剂与预后的关系

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摘要

The goal of our study was to analyse the prognostic values for some matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in breast cancer. We evaluated the activity and the expression levels of MMP-9, MMP-2, TIMP-1 and TIMP-2 in malignant versus benign fresh breast tumor extracts. For this purpose, gelatinzymography, immunoblotting and ELISA were used to analyse the activity and expression of MMPs and TIMPs. We found that MMP-9 expression level and activity are increased in malignant tumors. In addition, MMP-9/TIMP-1 and MMP-2/TIMP-2 ratio values obtained by us were significantly different in malignant tumors compared to benign tumors. We suggest that the abnormal MMP-9/TIMP-1 balance plays a role in the configuration of breast invasive carcinoma of no special type and also in tumor growth, while altered MMP-2/TIMP-2 ratio value could be associated with lymph node invasion and used as a prognostic marker in correlation with Nottingham Prognostic Index. Finally, we showed that in malignant tumors high expression of estrogen receptors is associated with enhanced activity of MMP-2 and increased bcl-2 levels, while high expression of progesterone receptors is correlated with low TIMP-1 protein levels.

机译：我们研究的目的是分析乳腺癌中某些基质金属蛋白酶（MMPs）和组织抑制剂金属基质金属蛋白酶（TIMPs）的预后价值。我们评估了恶性与良性新鲜乳腺肿瘤提取物中MMP-9，MMP-2，TIMP-1和TIMP-2的活性和表达水平。为此，使用明胶酶谱，免疫印迹和ELISA分析MMP和TIMP的活性和表达。我们发现在恶性肿瘤中MMP-9表达水平和活性增加。此外，与良性肿瘤相比，我们获得的MMP-9 / TIMP-1和MMP-2 / TIMP-2比率值在恶性肿瘤中有显着差异。我们建议异常的MMP-9 / TIMP-1平衡在无特殊类型的乳腺浸润癌的构型以及肿瘤的生长中起作用，而MMP-2 / TIMP-2比值的改变可能与淋巴结有关诺丁汉预后指数与预后指标相关。最后，我们表明在恶性肿瘤中，雌激素受体的高表达与MMP-2活性增强和bcl-2水平升高有关，而孕酮受体的高表达与TIMP-1蛋白水平低相关。

著录项

期刊名称 Journal of Cellular and Molecular Medicine
作者
D C Jinga; A Blidaru; Ileana Condrea; Carmen Ardeleanu; Cristina Dragomir; Geza Szegli; Maria Stefanescu; Cristiana Matache;
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作者单位

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年(卷),期 2006(10),2
年度 2006
页码 499–510
总页数 12
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
关键词
breast cancer MMP-9 MMP-2 TIMP-1 TIMP-2 clinicopathological markers;

机译：乳腺癌;MMP-9;MMP-2;TIMP-1;TIMP-2;临床病理标记;

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专利

1. MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors. [J] . Jinga DC, Blidaru A, Condrea I, Journal of cellular and molecular medicine. . 2006,第2期

机译：乳腺癌中MMP-9和MMP-2明胶酶以及TIMP-1和TIMP-2抑制剂：与预后因素的关系。
2. MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors [J] . D. C. Jinga, A. Blidaru, Ileana Condrea, Journal of cellular and molecular medicine. . 2006,第2期

机译：乳腺癌中MMP-9和MMP-2明胶酶以及TIMP-1和TIMP-2抑制剂：与预后因素的关系
3. Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis. [J] . Salata IM, Stojanovic N, Cajdler-Luba A, Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology . 2008,第6期

机译：子宫内膜异位症患者血清中的明胶酶A（MM-2），明胶酶B（MMP-9）及其抑制剂（TIMP 1，TIMP-2）：MMP-2，MMP-9及其抑制剂之间的显着相关性，但水平无差异子宫内膜异位症的严重程度与基质金属蛋白酶和金属蛋白酶组织抑制剂的关系
4. Evaluation of Matrix Metalloproteinase-9 (MMP-9) and its tissue inhibitor of metalloproteinase-1 (Timp-1) in patients with coronary syndromes after percutaneous intervention(PCI) [C] . Revnic F., Revnic C.R., Nica A., International Congress on Coronary Artery Disease . 2011

机译：经皮干预后冠状动脉综合征患者中基质金属蛋白酶-9（MMP-9）及其组织抑制剂及其组织抑制剂（PCI）
5. Exploring differences in breast cancer prognostic factors between Caucasian-American and African-American women in the United States. [D] . Krishnamoorthy, Sriya. 2007

机译：探索美国白人妇女和非洲裔美国妇女之间乳腺癌预后因素的差异。
6. Matrix Metalloproteinases MMP-2 and MMP-9 Their Inhibitors TIMP-1 and TIMP-2 Vascular Endothelial Growth Factor and sVEGFR-2 as Predictive Markers of Ischemic Retinopathy in Patients with Systemic Sclerosis—Case Series Report [O] . Arleta Waszczykowska, Michał Podgórski, Michał Waszczykowski, 2020

机译：基质金属蛋白酶MMP-2和MMP-9其抑制剂TIMP-1和TIMP-2血管内皮生长因子和SVEGFR-2作为系统性硬化症案例系列报告患者缺血性视网膜病变的预测标志
7. MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors [O] . D. C. Jinga, A. Blidaru, Ileana Condrea, 2006

机译：MMP-9和MMP-2凝胶酶和乳腺癌中的TIMP-2抑制剂：与预后因素的相关性

MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors

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