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首页> 美国卫生研究院文献>Cancer Science >Modulating Effects of Diets High in ω‐3 and ω‐6 Fatty Acids in Initiation and Postinitiation Stages of Diethylnitrosamine‐induced Hepatocarcinogenesis in Rats
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Modulating Effects of Diets High in ω‐3 and ω‐6 Fatty Acids in Initiation and Postinitiation Stages of Diethylnitrosamine‐induced Hepatocarcinogenesis in Rats

机译：饮食中ω-3和ω-6脂肪酸含量高的饮食在二乙基亚硝胺诱导的大鼠肝癌发生中的起始和起始阶段的调节作用

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The effects of sardine fish oil or corn oil on diethylnitrosamine (DEN)‐induced hepatocarcinogenesis were investigated in male F344 rats. Starting at 5 weeks of age, animals were divided into 11 groups and fed 23.5% corn oil (HCO) (groups 1 and 7) or 5% corn oil (LCO) (groups 2 and 8), 22.5% sardine oil + 1% corn oil (FO) semipurified diet (groups 3 and 9) or basal diet (CE‐2) (groups 4–6, 10 and 11). At 6 weeks of age, all animals except the vehicle‐treated groups were given DEN (200 mg/kg body weight, i.p. once weekly for 3 weeks). One week after the final exposure to DEN, groups 1–3 were changed to the basal diet, and groups 4–6 were switched to the HCO, LCO or FO diet, respectively. Animals in groups 1–3 and 10 were given drinking water containing 0.05% phenobarbital (PB). Liver sections from the animals at the termination of the experiment (24 weeks) were doubly stained for glutathione S‐transferase placental form (GST‐P) and silver‐stained nucleolar organizer regions (AgNORs). The multiplicity of hepatocellular neoplasms of group 1 was significantly larger than that of group 2 or 3. The number of GST‐P‐positive foci of group 2 or 3 was significantly smaller than that of group 1. Among the groups fed the experimental diets in the post initiation phase (groups 4–6), no significant difference was found in the incidence of liver tumors. AgNORs values of the enzyme‐altered foci in rats of the HCO diet groups were larger than those of the other diet groups. These results indicate that the enhancing effect of a high dose of corn oil in hepatocarcinogenesis is mainly present during the initiation phase but not during post initiation phase, and fish oil rich in polyunsaturated ω‐3 fatty acids could inhibit DEN‐induced hepatocarcinogenesis in rats.
机译：在雄性F344大鼠中研究了沙丁鱼鱼油或玉米油对二乙基亚硝胺（DEN）诱导的肝癌发生的影响。从5周龄开始，将动物分为11组，并喂食23.5％玉米油（HCO）（第1和7组）或5％玉米油（LCO）（第2和8组），22.5％沙丁鱼油+ 1％玉米油（FO）半纯化饮食（第3和9组）或基础饮食（CE-2）（第4-6、10和11组）。在6周龄时，除接受媒介物处理的组外，所有动物均给予DEN（200 mg / kg体重，每周3次，每周一次）。最终暴露于DEN后一周，第1-3组改为基础饮食，第4-6组分别改为HCO，LCO或FO饮食。第1-3组和第10组的动物喝含0.05％苯巴比妥（PB）的饮用水。在实验结束（24周）时，对动物的肝脏切片进行了谷胱甘肽S-转移酶胎盘形式（GST-P）和银染色的核仁组织者区域（AgNORs）的双重染色。第1组的肝细胞肿瘤的多样性显着大于第2或第3组。第2或第3组的GST-P阳性灶数量明显少于第1组。在开始阶段之后（第4-6组），肝肿瘤的发生率没有显着差异。 HCO饮食组大鼠的酶改变灶的AgNORs值大于其他饮食组。这些结果表明，高剂量玉米油对肝癌的增强作用主要存在于起始阶段，而在起始后阶段则不存在，富含多不饱和ω-3脂肪酸的鱼油可以抑制DEN诱导的大鼠肝癌的发生。

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