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首页> 美国卫生研究院文献>The Journal of General Physiology >Synaptic organization and ionic basis of on and off channels in mudpuppy retina. I. Intracellular analysis of chloride-sensitive electrogenic properties of receptors horizontal cells bipolar cells and amacrine cells
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Synaptic organization and ionic basis of on and off channels in mudpuppy retina. I. Intracellular analysis of chloride-sensitive electrogenic properties of receptors horizontal cells bipolar cells and amacrine cells

机译：泥mud视网膜内外通道的突触组织和离子基础。 I.受体水平细胞双极细胞和无长突细胞对氯化物敏感的电化特性的细胞内分析

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摘要

Intracellular recordings from receptors, horizontal cells, bipolars, and amacrines have been carried out in the perfused mudpuppy eyecup. The introduction of a chloride-free (c-f) medium results in initial transient potential changes in many cells followed by a slow loss of light-evoked activity of the depolarizing bipolar, the horizontal cell, and the on depolarization of amacrine cells. The hyperpolarizing bipolar remains responsive to light stimulation in a c-f medium, but the antagonistic surround mechanism is abolished. These effects are reversible after returning to a normal ionic medium. The results of this study provide insight into the retinal connections which underlie ganglion cell receptive field organization. It is concluded that the depolarizing bipolar is excitatory to on ganglion cells and is also the pathway for on-excitation of on-off cells. The hyperpolarizing bipolar mediates the off discharge of off and on-off cells. Amacrine cells receive input from both depolarizing and hyperpolarizing bipolar cells. These findings raise the possibility that transmembrane movements of chloride ions are critical for the light responsiveness of horizontal and depolarizing bipolar cell activity.
机译：来自受体，水平细胞，双极和无长突蛋白的细胞内记录已在灌注的泥mud眼罩中进行。引入无氯（c-f）培养基会导致许多细胞发生初始瞬态电势变化，随后使去极化双极型，水平细胞和无长春蓝素细胞去极化的光诱发活性缓慢丧失。超极化双极型在c-f介质中仍然对光刺激做出响应，但消除了拮抗作用的环绕机制。回到正常的离子介质后，这些作用是可逆的。这项研究的结果提供了深入了解神经节细胞感受野组织基础的视网膜连接。结论是，去极化双极对神经节细胞具有兴奋性，并且也是对开-关细胞进行激励的途径。超极化双极介导关闭和关闭电池的关闭放电。 Amacrine细胞从去极化和超极化双极细胞接收输入。这些发现增加了氯离子的跨膜运动对于水平和去极化双极细胞活性的光响应性至关重要的可能性。

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