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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice
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Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice

机译：Li草和苦瓜的乙醇提取物混合物对II型糖尿病小鼠的降血糖和抗血脂作用

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The extract of the Momordica charantia fruit (MCE) is recognized as an alternative treatment for diabetes. The extract of Ligularia fischeri leaves (LFE) is traditionally used as a folk medicine for treating inflammatory diseases in Korea as well. In this study, we investigated the synergistic effect of MCE combined with LFE on antihyperglycemic and antihyperlipidemic potentials. Based on the α-glucosidase inhibitory effect and promotion of adipocyte differentiation in the 3T3-L1 cell line, the MLM was prepared with MCE:LFE (8:2 weight:weight). MLM showed the synergistic effects in the promotion of the glucose uptake rate, suppression of dipeptidyl peptidase-4 (DPP-4) mRNA expression, upregulation of an insulin receptor substrate and glucose transporter type-4 expression, and an increase in insulin-associated signaling in C2C12 cells. In addition, the efficacy of peroxisome proliferator-activated receptor-γ agonism and glucose uptake rate by MLM supplementation was significantly enhanced in vitro. Then, the antihyperglycemic and antihyperlipidemic effects of MCE, LFE, and MLM at the dose of 50, 100, and 200 mg/kg/day (n = 6 per each group) were determined in streptozotocin (STZ)-insulted mice fed an atherogenic diet (ATH) for 4 weeks. In addition, MLM (50, 100, and 200 mg/kg/day, n = 5 per each group) was supplemented in ATH-fed db/db mice for 10 weeks. Compared with MCE or LFE alone, MLM supplementation led to a more significant reduction of glucose levels in both STZ/ATH and db/db/ATH mice as well as lowered lipid profiles in STZ/ATH mice. In addition, the stimulation of islet of Langerhans regeneration was more pronounced by MLM supplementation in both mice models. In conclusion, antihyperglycemic and antihyperlipidemic effects were strengthened by the combined extracts of L. fischeri and M. charantia (MLM) in diabetes-mimicking mice.
机译：苦瓜果实（MCE）的提取物被认为是糖尿病的替代疗法。丽Li叶提取物（LFE）在韩国传统上也被用作治疗炎性疾病的民间药物。在这项研究中，我们调查了MCE联合LFE对降血糖和降血脂潜力的协同作用。基于3T3-L1细胞系中α-葡糖苷酶的抑制作用和脂肪细胞分化的促进作用，用MCE：LFE（8：2重量：重量）制备MLM。 MLM在促进葡萄糖摄取速率，抑制二肽基肽酶-4（DPP-4）mRNA表达，胰岛素受体底物和葡萄糖转运蛋白4型表达的上调以及胰岛素相关信号的增加方面显示出协同作用。在C2C12细胞中另外，在体外，通过MLM补充的过氧化物酶体增殖物激活的受体-γ激动作用和葡萄糖摄取速率显着增强。然后，测定了链脲佐菌素（STZ）致动脉粥样硬化小鼠的MCE，LFE和MLM在50、100和200μmg/ kg /天的剂量（每组n = 6）时的降血糖和降血脂作用饮食（ATH）4周。此外，在ATH喂养的db / db小鼠中补充MLM（50、100和200μmg/ kg /天，每组n = 5），持续10周。与单独的MCE或LFE相比，补充MLM可导致STZ / ATH和db / db / ATH小鼠的血糖水平显着降低，并且STZ / ATH小鼠的血脂降低。另外，在两种小鼠模型中，通过补充传代糖对朗格汉斯再生的胰岛的刺激更加明显。总之，在模拟糖尿病的小鼠中，费氏乳杆菌和Charantia M. charantia（MLM）的联合提取物可增强抗血糖和降血脂作用。

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