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首页> 美国卫生研究院文献>Frontiers in Human Neuroscience >Brain lateralization and neural plasticity for musical and cognitive abilities in an epileptic musician
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Brain lateralization and neural plasticity for musical and cognitive abilities in an epileptic musician

机译：癫痫音乐家的音乐和认知能力的大脑偏侧化和神经可塑性

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The use of intracarotid propofol procedure (IPP) when assessing musical lateralization has not been reported in literature up to now. This procedure (similar to Wada Test) has provided the opportunity to investigate not only lateralization of language and memory functions on epileptic patients but also offers a functional mapping approach with superior spatial and temporal resolution to analyze the lateralization of musical abilities. Findings in literature suggest that musical training modifies functional and structural brain organization. We studied hemispheric lateralization in a professional musician, a 33 years old woman with refractory left medial temporal lobe (MTL) epilepsy (TLE). A longitudinal neuropsychological study was performed over a period of 21 months. Before epilepsy surgery, musical abilities, language and memory were tested during IPP by means of a novel and exhaustive neuropsychological battery focusing on the processing of music. We used a selection of stimuli to analyze listening, score reading, and tempo discrimination. Our results suggested that IPP is an excellent method to determine not only language, semantic, and episodic memory, but also musical dominance in a professional musician who may be candidate for epilepsy surgery. Neuropsychological testing revealed that right hemisphere's patient is involved in semantic and episodic musical memory processes, whereas her score reading and tempo processing require contribution from both hemispheres. At one-year follow-up, outcome was excellent with respect to seizures and professional skills, meanwhile cognitive abilities improved. These findings indicate that IPP helps to predict who might be at risk for postoperative musical, language, and memory deficits after epilepsy surgery. Our research suggests that musical expertise and epilepsy critically modifies long-term memory processes and induces brain structural and functional plasticity.
机译：迄今为止，尚无文献报道在评估音乐偏侧性时使用颈动脉内异丙酚手术（IPP）。该程序（类似于Wada测试）不仅为研究癫痫患者的语言和记忆功能的偏侧化提供了机会，而且还提供了一种具有出色时空分辨率的功能映射方法来分析音乐能力的偏侧化。文献中的发现表明，音乐训练会改变大脑的功能和结构。我们在一名专业音乐家中研究了半球偏侧症，一名33岁的女性患有难治性左内侧颞叶（MTL）癫痫病（TLE）。进行了为期21个月的纵向神经心理学研究。在癫痫手术之前，IPP期间通过专注于音乐处理的新颖而详尽的神经心理学方法对音乐能力，语言和记忆进行了测试。我们使用了一系列刺激来分析听力，乐谱阅读和速度区分。我们的结果表明，IPP是一种不仅可以确定语言，语义和情节记忆的方法，而且可以确定可能是癫痫手术候选者的专业音乐家的音乐主导地位。神经心理学测试表明，右半球的患者参与了语义和情景音乐的记忆过程，而她的乐谱阅读和节奏处理需要两个半球的贡献。在一年的随访中，癫痫发作和专业技能的治疗效果极佳，同时认知能力得到了改善。这些发现表明IPP有助于预测癫痫手术后谁可能有术后音乐，语言和记忆缺陷的风险。我们的研究表明，音乐专长和癫痫症会严重改变长期记忆过程并诱发大脑结构和功能可塑性。

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