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Modeling vaccination campaigns and the Fall/Winter 2009 activity of the new A(H1N1) influenza in the Northern Hemisphere

机译:对北半球新型A(H1N1)流感的疫苗接种运动和2009年秋/冬活动进行建模

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摘要

The unfolding of pandemic influenza A(H1N1) for Fall 2009 in the Northern Hemisphere is still uncertain. Plans for vaccination campaigns and vaccine trials are underway, with the first batches expected to be available early October. Several studies point to the possibility of an anticipated pandemic peak that could undermine the effectiveness of vaccination strategies. Here, we use a structured global epidemic and mobility metapopulation model to assess the effectiveness of massive vaccination campaigns for the Fall/Winter 2009. Mitigation effects are explored depending on the interplay between the predicted pandemic evolution and the expected delivery of vaccines. The model is calibrated using recent estimates on the transmissibility of the new A(H1N1) influenza. Results show that if additional intervention strategies were not used to delay the time of pandemic peak, vaccination may not be able to considerably reduce the cumulative number of cases, even when the mass vaccination campaign is started as early as mid-October. Prioritized vaccination would be crucial in slowing down the pandemic evolution and reducing its burden.
机译:北半球2009年秋季爆发的甲型H1N1大流行性流感仍不确定。疫苗接种运动和疫苗试验的计划正在进行中,预计第一批将在10月初上市。几项研究指出,预期的大流行高峰可能破坏疫苗接种策略的有效性。在这里,我们使用结构化的全球流行病和流动性人口模型来评估2009年秋冬季大规模疫苗接种运动的有效性。根据预计的大流行病演变与预期疫苗交付之间的相互作用,研究缓解效果。该模型使用对新的A(H1N1)流感的可传播性的最新估计值进行了校准。结果表明,如果不使用其他干预策略来延迟大流行高峰的时间,即使最早于10月中旬开始大规模疫苗接种运动,疫苗接种也可能无法显着减少累计病例数。优先接种疫苗对于减缓大流行的发展速度并减轻其负担至关重要。

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