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首页> 美国卫生研究院文献>The Pan African Medical Journal >Hemolytic anemia caused by non-D minor blood incompatibilities in a newborn
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Hemolytic anemia caused by non-D minor blood incompatibilities in a newborn

机译：新生儿非D型血液不相容引起的溶血性贫血

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摘要

Hyperbilirubinemia is one of the most widely seen cause of neonatal morbidity. Besides ABO and Rh isoimmunization, minor blood incompatibilities have been also been identified as the other causes of severe newborn jaundice. We report a newborn with indirect hyperbilirubinemia caused by minor blood group incompatibilities (P1, M, N, s and Duffy) whose hemolysis was successfully managed with intravenous immunoglobulin therapy. A thirty-two gestational weeks of preterm male baby became severely icteric on postnatal day 11, with a total bilirubin level of 14.66 mg/dl. Antibody screening tests revealed incompatibility on different minor groups (P1, M, N, s and Duffy (Fya ve Fyb)). On postnatal day thirteen, the level of bilirubin increased to 20.66 mg/dl although baby was under intensive phototherapy. After the administration of intravenous immunoglobulin and red blood cell transfusion, hemoglobin and total bilirubin levels became stabilised. Minor blood incompatibilities should be kept in mind during differential diagnosis of hemolytic anemia of the newborn. They share the same treatment algorithm with the other types hemolytic anemia. New studies revealed that intravenous immunoglobulin treatment in hemolytic anemia have some attractive and glamorous results. It should be seriously taken into consideration for treatment of minor blood incompatibilities.
机译：高胆红素血症是新生儿发病率最广泛的原因之一。除了ABO和Rh的同种免疫外，轻微的血液不相容性也被确定为严重新生儿黄疸的其他原因。我们报告了由轻微血型不合（P1，M，N，s和Duffy）引起的间接高胆红素血症新生儿，其溶血通过静脉内免疫球蛋白疗法成功进行。在出生后的第11天，早孕的32个孕周男婴黄疸严重，总胆红素水平为14.66 mg / dl。抗体筛选测试显示不同的少数群体（P1，M，N，s和Duffy（Fya ve Fyb））不兼容。在出生后的第十三天，尽管婴儿正在接受强光疗，但胆红素水平仍增至20.66 mg / dl。静脉注射免疫球蛋白和红细胞输注后，血红蛋白和总胆红素水平变得稳定。在新生儿溶血性贫血的鉴别诊断中应牢记轻微的血液不相容性。他们与其他类型的溶血性贫血共享相同的治疗算法。新的研究表明，静脉内免疫球蛋白治疗溶血性贫血有一些吸引人的魅力。治疗轻微血液不相容性时应认真考虑。

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