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首页> 美国卫生研究院文献>Frontiers in Psychiatry >Comorbidity of Obsessive-Compulsive Disorder and Schizotypal Personality Disorder: Clinical Response and Treatment Resistance to Pharmacotherapy in a 3-Year Follow-Up Naturalistic Study
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Comorbidity of Obsessive-Compulsive Disorder and Schizotypal Personality Disorder: Clinical Response and Treatment Resistance to Pharmacotherapy in a 3-Year Follow-Up Naturalistic Study

机译：强迫症和精神分裂型人格障碍的合并症：一项为期3年的随访自然主义研究对药物治疗的临床反应和治疗抵抗

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The present study aims to analyze the clinical and socio-demographic characteristics of patients with obsessive-compulsive disorder (OCD) in comorbidity with schizotypal personality disorder (SPD), as well as the response rate to pharmacological treatments. OCD+SPD patients had a younger age at onset, a higher probability to have more severe obsessive-compulsive symptoms, a higher rate of schizophrenia spectrum disorders in their first-degree relatives, and a poorer insight compared to OCD patients. During the 3-year follow-up period, these patients showed a lower rate of recovery, thus requiring augmentation with different psychotropic medications, including low doses of antipsychotics. Our findings suggest that the comorbidity of OCD and SPD causes a poor treatment response, and a reduced probability to recover using standard pharmacological treatment strategies. Further investigations are needed to identify alternative strategies, including psychoeducation and cognitive behavioral therapy, to manage such frequent comorbidity in clinical practice.
机译：本研究旨在分析伴有精神分裂型人格障碍（SPD）的强迫症（OCD）患者的临床和社会人口统计学特征，以及对药物治疗的反应率。与OCD患者相比，OCD + SPD患者发病年龄更年轻，出现更严重的强迫症症状的可能性更高，一级亲属中的精神分裂症谱系障碍的发生率更高，洞察力也较差。在3年的随访期内，这些患者的康复率较低，因此需要增加不同的精神药物，包括低剂量的抗精神病药。我们的发现表明，OCD和SPD合并症会导致较差的治疗反应，并降低使用标准药物治疗策略恢复的可能性。需要进一步的研究来确定替代策略，包括心理教育和认知行为疗法，以在临床实践中管理这种常见的合并症。

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