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Enhanced mechanical thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering

机译：用于骨组织工程的双组分电纺纳米复合材料的增强的机械热和生物相容性

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Traditionally, in the Asian continent, oils are a widely accepted choice for alleviating bone-related disorders. The design of scaffolds resembling the extracellular matrix (ECM) is of great significance in bone tissue engineering. In this study, a multicomponent polyurethane (PU), canola oil (CO) and neem oil (NO) scaffold was developed using the electrospinning technique. The fabricated nanofibers were subjected to various physicochemical and biological testing to validate its suitability for bone tissue engineering. Morphological analysis of the multicomponent scaffold showed a reduction in fiber diameter (PU/CO—853 ± 141.27 nm and PU/CO/NO—633 ± 137.54 nm) compared to PU (890 ± 116.911 nm). The existence of CO and NO in PU matrix was confirmed by an infrared spectrum (IR) with the formation of hydrogen bond. PU/CO displayed a mean contact angle of 108.7° ± 0.58 while the PU/CO/NO exhibited hydrophilic nature with an angle of 62.33° ± 2.52. The developed multicomponent also exhibited higher thermal stability and increased mechanical strength compared to the pristine PU. Atomic force microscopy (AFM) analysis depicted lower surface roughness for the nanocomposites (PU/CO—389 nm and PU/CO/NO—323 nm) than the pristine PU (576 nm). Blood compatibility investigation displayed the anticoagulant nature of the composites. Cytocompatibility studies revealed the non-toxic nature of the developed composites with human fibroblast cells (HDF) cells. The newly developed porous PU nanocomposite scaffold comprising CO and NO may serve as a potential candidate for bone tissue engineering.
机译：传统上，在亚洲大陆，油是缓解骨骼相关疾病的广泛接受的选择。类似于细胞外基质（ECM）的支架的设计在骨组织工程中具有重要意义。在这项研究中，使用电纺技术开发了一种多组分聚氨酯（PU），菜籽油（CO）和印em油（NO）支架。对制成的纳米纤维进行了各种物理化学和生物学测试，以验证其对骨组织工程的适用性。与PU（890±116.911 nm）相比，多组分支架的形态学分析显示纤维直径减小（PU / CO-853±141.27 nm和PU / CO / NO-633±137.54 nm）。通过形成氢键的红外光谱（IR）证实了PU基体中CO和NO的存在。 PU / CO的平均接触角为108.7°±0.58，而PU / CO / NO的亲水性为62.33°±2.52。与原始PU相比，开发的多组分还表现出更高的热稳定性和更高的机械强度。原子力显微镜（AFM）分析显示，纳米复合材料的表面粗糙度（PU / CO-389 nm和PU / CO / NO-323 nm）比原始PU（576 nm）低。血液相容性研究显示了复合材料的抗凝特性。细胞相容性研究揭示了已开发的具有人类成纤维细胞（HDF）细胞的复合材料的无毒性质。新开发的包含CO和NO的多孔PU纳米复合材料支架可作为骨组织工程的潜在候选者。

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