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首页> 美国卫生研究院文献>Frontiers in Psychiatry >Disrupted Resting Frontal–Parietal Attention Network Topology Is Associated With a Clinical Measure in Children With Attention-Deficit/Hyperactivity Disorder
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Disrupted Resting Frontal–Parietal Attention Network Topology Is Associated With a Clinical Measure in Children With Attention-Deficit/Hyperactivity Disorder

机译：注意力不集中/多动症患儿的休息休息额-顶叶注意力网络拓扑结构与临床措施相关

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>Purpose: Although alterations in resting-state functional connectivity between brain regions have been reported in children with attention-deficit/hyperactivity disorder (ADHD), the spatial organization of these changes remains largely unknown. Here, we studied frontal–parietal attention network topology in children with ADHD, and related topology to a clinical measure of disease progression. >Methods: Resting-state fMRI scans were obtained from New York University Child Study Center, including 119 children with ADHD (male n = 89; female n = 30) and 69 typically developing controls (male n = 33; female n = 36). We characterized frontal–parietal functional networks using standard graph analysis (clustering coefficient and shortest path length) and the construction of a minimum spanning tree, a novel approach that allows a unique and unbiased characterization of brain networks. >Results: Clustering coefficient and path length in the frontal–parietal attention network were similar in children with ADHD and typically developing controls; however, diameter was greater and leaf number, tree hierarchy, and kappa were lower in children with ADHD, and were significantly correlated with ADHD symptom score. There were significant alterations in nodal eccentricity in children with ADHD, involving prefrontal and occipital cortex regions, which are compatible with the results of previous ADHD studies. >Conclusions: Our results indicate the tendency to deviate from a more centralized organization (star-like topology) towards a more decentralized organization (line-like topology) in the frontal–parietal attention network of children with ADHD. This represents a more random network that is associated with impaired global efficiency and network decentralization. These changes appear to reflect clinically relevant phenomena and hold promise as markers of disease progression.
机译：>目的：尽管据报道患有注意力缺陷/多动障碍（ADHD）的儿童大脑区域之间的静止状态功能连接发生了变化，但这些变化的空间组织仍然未知。在这里，我们研究了多动症儿童的额叶顶注意力网络拓扑，以及与疾病进展的临床测量相关的拓扑。 >方法：从纽约大学儿童研究中心获得静息态fMRI扫描，包括119名多动症患儿（男n = 89；女n = 30）和69名典型的发育中对照（男n = 33） ；女性n = 36）。我们使用标准图形分析（聚类系数和最短路径长度）和最小生成树的构造来表征额顶功能网络，这是一种新颖的方法，可以对大脑网络进行独特且无偏见的表征。 >结果：ADHD儿童的额叶-顶叶注意力网络中的聚类系数和路径长度相似，并且通常发展为对照组；然而，多动症儿童的直径更大，叶数，树的层次和kappa更低，并且与多动症症状评分显着相关。 ADHD患儿的节点偏心率有明显改变，涉及额叶前额和枕叶皮质区域，这与以前的ADHD研究结果相符。 >结论：我们的结果表明，多动症儿童的额叶顶注网络中，趋势从集中的组织（星形拓扑）转向分散的组织（线形拓扑）。这代表了一个随机性更高的网络，这与削弱的全球效率和网络分散有关。这些变化似乎反映了临床相关现象，并有望成为疾病进展的标志。

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