首页> 美国卫生研究院文献>Particle and Fibre Toxicology >Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

【2h】

Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

机译：低毒性等距生物持久性颗粒的职业暴露水平（OELs）的推导：如何利用动态肺超负荷范式改进吸入毒性研究设计和OEL推导？

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundConvincing evidence suggests that poorly soluble low-toxicity particles (PSP) exert two unifying major modes of action (MoA), in which one appears to be deposition-related acute, whilst the other is retention-related and occurs with particle accumulation in the lung and associated persistent inflammation. Either MoA has its study- and cumulative dose-specific adverse outcome and metric. Modeling procedures were applied to better understand as to which extent protocol variables may predetermine any specific outcome of study. The results from modeled and empirical studies served as basis to derive OELs from modeled and empirically confirmed directions.

机译：背景令人信服的证据表明，难溶性低毒性颗粒（PSP）发挥两种统一的主要作用方式（MoA），其中一种似乎是与沉积有关的急性反应，而另一种是与保留有关的，并且与肺中的颗粒堆积有关和相关的持续性炎症。 MoA都有其针对研究和累积剂量的不良结果和指标。应用建模程序可以更好地了解协议变量可以在多大程度上预先确定研究的任何特定结果。建模和实证研究的结果可作为从建模和实证确认的方向得出OEL的基础。

著录项

期刊名称 Particle and Fibre Toxicology
作者
Jürgen Pauluhn;
展开▼
作者单位

展开▼
年(卷),期 2014(11),-1
年度 2014
页码 72
总页数 14
原文格式 PDF
正文语种
中图分类毒物学（毒理学）;
关键词
Nano-size particles Micronsized particles Repeated inhalation exposure Disposition Dissolution Volume displacement lung overload;

机译：纳米级颗粒;微米级颗粒;反复吸入暴露;处置;溶解;体排量肺过载;

相似文献

外文文献

1. Study of TiO2 P25 Nanoparticles Genotoxicity on Lung, Blood, and Liver Cells in Lung Overload andNon-Overload ConditionsAfter Repeated Respiratory Exposure in Rats [J] . Relier Charlene, Dubreuil Marielle, Garcia Omar Lozano, Toxicological sciences: An official journal of the Society of Toxicology . 2017,第2期

机译：肺，血液和肝细胞在肺，血液和肝细胞中的TiO2 P25纳米粒子遗传毒性研究大鼠重复呼吸暴露的反复呼吸道暴露
2. Derivation of occupational exposure limits for multi-walled carbon nanotubes and graphene using subchronic inhalation toxicity data and a multi-path particle dosimetry model [J] . Lee Young-Sub, Sung Jae-Hyuck, Song Kyung-Seuk, Toxicology Research . 2019,第4期

机译：使用副级吸入毒性数据和多路径粒子剂量模型衍生多壁碳纳米管和石墨烯的职业暴露限制
3. A 13-week nose-only inhalation toxicity study for perfluoro-n-butyl iodide (PFBI) in rats with recommended occupational exposure levels. [J] . Mattie DR, Hoffman GM, Narayanan L, Inhalation toxicology . 2010,第9a11期

机译：为期13周的全氟正丁基碘（PFBI）在建议职业接触水平下的大鼠的仅鼻吸吸入毒性研究。
4. Derivation of occupational exposure limits for multi-walled carbon nanotubes and graphene using subchronic inhalation toxicity data and a multi-path particle dosimetry model [O] . Young-Sub Lee, Jae-Hyuck Sung, Kyung-Seuk Song, 2019

机译：利用亚慢性吸入毒性数据和多径颗粒剂量模型推导多壁碳纳米管和石墨烯的职业接触限值
5. Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation? [O] . 2014

机译：低毒性等距生物持久性颗粒的职业暴露水平（OELs）的推导：如何利用动态肺超负荷范式改进吸入毒性研究设计和OEL推导？
6. Acute Inhalation Toxicity of Pyrolysis Products of Halon 1301: Kinetic Course of Lung Injury, Degradation in Work Performance, and Exercise Potentiation of Lung Injury after Phosgene Exposure. [R] . Lehnert, B. E. 1992

机译：哈龙1301热解产物的急性吸入毒性：光气暴露后肺损伤的动力学过程，工作性能的退化和肺损伤的运动增强。

Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

摘要

著录项

相似文献

相关主题

期刊订阅