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首页> 美国卫生研究院文献>other >Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia
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Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia

机译：中风前手术对经历60分钟短暂性局灶性脑缺血的血压正常的大鼠无益

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Experimental stroke in rodents, via middle cerebral artery occlusion (MCAO), can be associated with a negative impact on wellbeing and mortality. In hypertensive rodents, pre-stroke craniotomy increased survival and decreased body weight loss post-MCAO. Here we determined the effect, in normotensive Sprague-Dawley rats following 60 minutes MCAO, with or without pre-surgical craniotomy, on post-stroke outcomes in terms of weight loss, neurological deficit, lesion volume and functional outcomes. There was no effect of pre-stroke craniotomy on indicators of wellbeing including survival rate (P = 0.32), body weight loss (P = 0.42) and neurological deficit (P = 0.75). We also assessed common outcome measures following experimental stroke and found no effect of pre-stroke craniotomy on lesion volume as measured by T2-weighted MRI (P = 0.846), or functional performance up to 28 days post-MCAO (staircase test, P = 0.32; adhesive sticker test, P = 0.49; cylinder test, P = 0.38). Thus, pre-stroke craniotomy did not improve animal welfare in terms of body weight loss and neurological deficit. However, it is important, given that a number of drug delivery studies utilise the craniotomy procedure, to note that there was no effect on lesion volume or functional outcome following experimental stroke.
机译：通过大脑中动脉闭塞（MCAO）在啮齿动物中进行的实验性中风可能对健康和死亡率产生负面影响。在高血压啮齿动物中，中风前开颅手术可增加生存，并降低MCAO后的体重减轻。在这里，我们确定了正常血压的Sprague-Dawley大鼠MCAO 60分钟后，无论是否进行手术前颅骨切开术，均在体重减轻，神经功能缺损，病变体积和功能结局方面对中风后结局产生影响。脑卒中前开颅手术对健康指标没有影响，包括生存率（P = 0.32），体重减轻（P = 0.42）和神经功能缺损（P = 0.75）。我们还评估了实验性卒中后的常见结局指标，发现经T2加权MRI（P = 0.846）或在MCAO后长达28天的功能表现（楼梯测试，P = 0.32；不干胶标签测试，P = 0.49；圆筒测试，P = 0.38）。因此，脑卒中前开颅手术在体重减轻和神经功能缺损方面并未改善动物福利。但是，重要的是，考虑到许多药物输送研究都采用了开颅手术，因此要注意，实验性卒中后对病变体积或功能结局没有影响。

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