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EARLY LIFE RISK FACTORS FOR FRAILTY AMONG COMMUNITY-DWELLING CHINESE OLDER ADULTS

机译：中国社区老年居民中的早期寿命危险因素

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Frailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes. However, little is known about the influence of early-life risk factors on frailty in old age. This study aimed to examine the associations between early-life factors and frailty among community-dwelling Chinese elders. Data are from the China Health and Retirement Longitudinal Study on 6,806 adults aged ≥60 years. Frailty was assessed by the physical frailty scale based on 5 criteria: weakness, slowness, exhaustion, inactivity, and shrinking. We classified individuals with 0, 1–2, and 3–5 criteria as “non-frail”, “prefrail,” and “frail,” respectively. Early-life factors include education (self, maternal, paternal), financial situation, food security, neighborhood environment, domestic violence, and child health status. Chi-squared test was used to examine the unadjusted association between each early-life factor and frailty; significant risk factors were modeled simultaneously in a multinomial regression. In total, 2,409 (35.4%) were non-frail, 3,849 (56.6%) were prefrail, and 548 (8.1%) were frail. Education, paternal education, neighborhood environment, and child health status were significantly associated with frailty, after adjusting for sex and age. The risk of frailty (vs. non-frailty) was 32% lower among individuals whose fathers with at least primary school education than those who didn’t. Each point higher on a neighborhood environment scale was associated with a 29.4% higher risk of frailty. Unhealthy childhood status doubled the risk of frailty. This study identified several novel early life risk factors for frailty among Chinese older adults. Future research needs to elucidate mechanisms medicating these associations.
机译：身体虚弱是一种与年龄相关的临床综合征，其对压力源的抵抗力下降，并与许多不良后果相关。但是，关于早期生命危险因素对衰老的影响知之甚少。这项研究旨在研究中国社区居民中老年人的早期生活因素与虚弱之间的联系。数据来自《中国卫生与退休纵向研究》，研究对象为6806名年龄在60岁以上的成年人。根据身体虚弱量表，基于5个标准评估虚弱程度：虚弱，缓慢，疲惫，不运动和萎缩。我们将具有0、1-2和3-5标准的个人分别分类为“不脆弱”，“预脆弱”和“脆弱”。早期的因素包括受教育程度（自己，母亲，父亲），财务状况，粮食安全，邻里环境，家庭暴力和儿童健康状况。卡方检验用于检验各个早期因素与衰弱之间的未经调整的关联；多项回归同时建立了重要的风险因素模型。共有2409（35.4％）人为不脆弱，3,849（56.6％）人为脆弱，而548（8.1％）人为脆弱。在调整了性别和年龄之后，教育，家长教育，邻里环境和儿童健康状况与体弱相关。在父亲中至少受过小学教育的人比没有父亲受过教育的人，身体虚弱（相对于非身体虚弱）的风险要低32％。在邻里环境规模上每提高一点，脆弱的风险就增加29.4％。童年时期不健康的状况使脆弱的风险增加了一倍。这项研究确定了一些新的早期中国老年人衰弱的危险因素。未来的研究需要阐明治疗这些关联的机制。

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    Y Li; C Wu;

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  • 年(卷),期 -1(2),Suppl 1
  • 年度 -1
  • 页码 945
  • 总页数 1
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