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首页> 美国卫生研究院文献>other >Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?
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Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?

机译：神经肌肉疾病6分钟步行测试期间2分钟步行距离与6分钟步行距离：2分钟步行测试是否可以有效替代6分钟步行测试？

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摘要

Functional tests such as Motor Function Measure-32 (MFM-32), supine to stand, ascend/ descend stairs permit the assessment of task-specific motor function in neuromuscular disease (NMD). The 6-min walk test (6MWT), though functional, is primarily used to assess endurance and disease progression in children with neuromuscular disorders. Barriers to 6MWT administration, in this population, can include reduced attention span due to age and inability to tolerate test length due to weakness. We propose task-specific functional deficits are related to endurance. Additionally, the 2-min walk test (2MWT) could effectively replace the 6MWT in this population. Seventy-seven participants, ages 5—18, with a variety of neuromuscular disorders performed the 6MWT, timed functional tests (TFT), and the MFM-32. Correlation and paired t-test analyses were used to compare the distance walked in the first 2 min (2MWD) to the distance walked in the entire 6 min (6MWD) and to the functional outcome measures above. The 2MWD strongly correlated with 6MWD and the other outcome measures. Paired t-test analysis also showed that the 2MWD did not differ from the distance walked in the last 2 min of the 6MWT. Although equivalence testing could not reject the claim that this difference exceeded the upper practical limit of 9.5 m, it only showed a modest overestimation of the 4–6MWD compared with the 2MWD. Together, our results support the ability of the 2MWD to predict the 6MWD, specifically in the pediatric neuromuscular disease population.
机译：功能测试，例如运动功能测量32（MFM-32），仰卧站立，上升/下降楼梯，可以评估神经肌肉疾病（NMD）中特定任务的运动功能。 6分钟步行测试（6MWT）虽然有效，但主要用于评估神经肌肉疾病患儿的耐力和疾病进展。在这一人群中，进行6MWT的障碍可能包括由于年龄而引起的注意力减少和由于虚弱而无法忍受测试时间。我们建议特定任务的功能缺陷与耐力有关。此外，2分钟步行测试（2MWT）可以有效替代该人群中的6MWT。患有各种神经肌肉疾病的77岁，5-18岁的参与者进行了6MWT，定时功能测试（TFT）和MFM-32。相关性和配对t检验分析用于比较前2分钟（2MWD）的步行距离，整个6分钟（6MWD）的步行距离以及上述功能结果指标。 2MWD与6MWD和其他结果指标密切相关。配对t检验分析还显示2MWD与6MWT最后2分钟的步行距离没有差异。尽管等效测试不能拒绝这种差异超出实际上限9.5 m的说法，但与2MWD相比，它仅显示了4-6MWD的适度高估。总之，我们的结果支持2MWD预测6MWD的能力，特别是在小儿神经肌肉疾病人群中。

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