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首页> 美国卫生研究院文献>Frontiers in Psychiatry >Increased Inhibition of the Amygdala by the mPFC may Reflect a Resilience Factor in Post-traumatic Stress Disorder: A Resting-State fMRI Granger Causality Analysis
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Increased Inhibition of the Amygdala by the mPFC may Reflect a Resilience Factor in Post-traumatic Stress Disorder: A Resting-State fMRI Granger Causality Analysis

机译：mPFC对杏仁核的抑制作用增强可能反映了创伤后应激障碍的恢复力因素：静息状态fMRI Granger因果关系分析

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>Purpose: To determine whether effective connectivity of the amygdala is altered in traumatized subjects with and without post-traumatic stress disorder (PTSD).>Materials and Methods: Resting-state functional MRI data were obtained for 27 patients with typhoon-related PTSD, 33 trauma-exposed controls (TEC), and 30 healthy controls (HC). Effective connectivity of the bilateral amygdala was examined with Granger causality analysis and then compared between groups by conducting an analysis of variance.>Results: Compared to the HC group, both the PTSD group and the TEC group showed increased effective connectivity from the amygdala to the medial prefrontal cortex (mPFC). The TEC group showed increased effective connectivity from the mPFC to the amygdala relative to the HC group. Compared to the TEC group, the PTSD group showed increased effective connectivity from the amygdala to the supplementary motor area (SMA), whereas decreased effective connectivity was detected from the SMA to the amygdala. Both the PTSD group and the TEC group showed decreased effective connectivity from the superior temporal gyrus (STG) to the amygdala relative to the HC group. Compared to the HC group, the TEC group showed increased effective connectivity from the amygdala to the dorsolateral prefrontal cortex (dlPFC), while both the PTSD group and the TEC group showed decreased effective connectivity from the dlPFC to the amygdala. The PTSD group showed decreased effective connectivity from the precuneus to the amygdala relative to both control groups, but increased effective connectivity from the amygdala to the precuneus relative to the HC group.>Conclusion: Trauma leads to an increased down-top excitation from the amygdala to the mPFC and less regulation of the amygdala by the dlPFC. The results suggest that increased inhibition of the amygdala by the mPFC may reflect a resilience factor, and altered amygdala-SMA and amygdala-STG effective connectivity may reflect compensatory mechanisms of brain function. These data raise the possibility that insufficient inhibition of the amygdala by the mPFC might lead to PTSD in those who have been exposed to traumatic incidents, and may inform future therapeutic interventions.
机译：>目的：确定在患有和没有创伤后应激障碍（PTSD）的受过创伤的受试者中杏仁核的有效连通性是否发生改变。>材料和方法：静息状态功能性MRI获得了27例台风相关PTSD患者，33例暴露于创伤的对照（TEC）和30例健康对照（HC）的数据。通过格兰杰因果关系分析检查双侧杏仁核的有效连通性，然后通过进行方差分析比较各组之间的差异。>结果：与HC组相比，PTSD组和TEC组均显示出有效的增加从杏仁核到内侧前额叶皮层（mPFC）的连通性。与HC组相比，TEC组显示了从mPFC到杏仁核的有效连通性增加。与TEC组相比，PTSD组显示出从杏仁核到辅助运动区（SMA）的有效连通性增加，而从SMA到杏仁核的有效连通性下降。相对于HC组，PTSD组和TEC组均显示从颞上回（STG）到杏仁核的有效连通性降低。与HC组相比，TEC组显示出从杏仁核到背外侧前额叶皮层（dlPFC）的有效连通性增加，而PTSD组和TEC组均显示出从dlPFC到杏仁核的有效连通性降低。相对于两个对照组，PTSD组显示从前核到杏仁核的有效连通性降低，但相对于HC组，从扁桃体到杏仁核的有效连通性增加。>结论：创伤导致下肢增加从杏仁核到mPFC的顶部兴奋，而dlPFC对杏仁核的调节较少。结果表明，mPFC对杏仁核的抑制作用增强可能反映了弹性因子，而杏仁核SMA和杏仁核STG有效连接性的改变可能反映了脑功能的补偿机制。这些数据提出了以下可能性：mPFC对杏仁核的抑制不足可能导致遭受创伤事件的患者发生PTSD，并可能为将来的治疗干预提供依据。

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