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首页> 美国卫生研究院文献>other >Characteristics of contrast-enhanced ultrasound in distinguishing small (≤3 cm) hepatocellular carcinoma from intrahepatic cholangiocarcinoma
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Characteristics of contrast-enhanced ultrasound in distinguishing small (≤3 cm) hepatocellular carcinoma from intrahepatic cholangiocarcinoma

机译：超声造影在区分小（≤3cm）肝细胞癌和肝内胆管癌中的特征

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Contrast-enhanced ultrasound (CEUS) is highly accurate in depicting the vascularity of liver nodules. The aim of this study was to verify the characteristics of CEUS in distinguishing small (≤3 cm) hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC).A total of 65 patients with a liver nodule (HCC, n = 58; ICC, n = 7) smaller than 3 cm who underwent liver CEUS and pathologic confirmation were retrospectively reviewed. CEUS findings were compared with histopathologic and clinical data.Arterial-phase hyperenhancement and portal-delayed-phase wash-out on CEUS were observed in 77.6% (45/58) of HCCs and 85.7% (6/7) of ICCs. Time of arterial-phase hyperenhancement (11 seconds [6–20] vs 16 seconds [14–19], P = .008), time of portal-delayed-phase wash-out (65 seconds (15–260) vs 35 secconds (27–54), P = .002), and time interval between arterial-phase hyperenhancement and portal-delayed-phase wash-out (50 seconds [5–249] vs 19 seconds [13–35], P < .001) on CEUS were significantly different between HCCs and ICCs showing arterial-phase hyperenhancement and portal-delayed-phase wash-out. The sensitivity, specificity, positive predictive value, and negative predictive value of time interval more than 25 seconds between arterial-phase hyperenhancement and portal-delayed-phase wash-out on CEUS for the differentiation of HCCs and ICCs were 91.1%, 83.3%, 97.6%, and 55.6%, respectively.The time interval between arterial-phase hyperenhancement and portal-delayed-phase wash-out on CEUS was the most sensitive indicator in distinguishing small HCC from ICC showing arterial-phase hyperenhancement and portal-delayed-phase wash-out.
机译：造影增强超声（CEUS）在描绘肝结节的血管形成方面非常准确。这项研究的目的是验证CEUS在区分小（≤3cm）肝细胞癌（HCC）和肝内胆管癌（ICC）中的特征。共65例肝结节（HCC，n == 58; ICC，回顾性分析行肝脏CEUS检查的小于3 cm的n = 7）。将CEUS的发现与组织病理学和临床数据进行比较。在CEUS中，有77.6％（45/58）的HCC和85.7％（6/7）的ICC观察到CEUS的动脉期过度增强和门静脉延迟期冲洗。动脉期超增强时间（11秒[6-20] vs 16秒[14-19]，P = .008），门脉延迟期冲洗时间（65秒（15-260）对35 vs秒） （27–54），P = .002），以及动脉期超增强和门脉延迟期冲洗之间的时间间隔（50秒[5–249] vs 19秒[13–35]，P <.001） ）CEUS在HCC和ICC之间存在显着差异，表现出动脉期过度增强和门脉延迟期冲洗。在CEUS上，动脉期超增强和门静脉延迟期冲洗之间的时间间隔大于25秒的敏感性，特异性，阳性预测值和阴性预测值对HCC和ICC的区分分别为91.1％，83.3％，在CEUS上动脉相超增强和门脉延迟相清除之间的时间间隔是区分小肝癌和ICC的最敏感指标，表现为动脉相超增强和门脉延迟相洗掉。

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