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Heterogeneity analysis of triphasic CT scan perfusion parameters in differential diagnosis of hepatocellular carcinoma and hemangioma

机译：三期CT扫描灌注参数的异质性分析在肝癌和血管瘤鉴别诊断中的应用。

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This study is to investigate quantitative measures and heterogeneity of perfusion parameters in the differential diagnosis of hepatocellular carcinoma (HCC) and hemangioma.In total, 32 HCC and 44 hemangioma (types 1, 2, and 3) cases were included in this retrospective study. Hepatic artery coefficient (HAC), portal vein coefficient (PVC), and arterial enhancement fraction (AEF) were calculated. Tumor heterogeneity was analyzed. Perfusion parameters and corresponding percentiles were compared between the HCC and hemangioma (especially atypical hemangioma) cases, as well as between the substantial lesion part and surrounding normal tissue.The mean value, and the 10th, 50th, 75th, and 90th percentiles of PVC were significantly lower in the HCC cases than the types 1 and 2 hemangioma cases (P < .01). Moreover, the 90th percentile PVC in the HCC cases was also significantly lower than the type 3 hemangioma case (P < .01), while the mean value, and all the percentiles of AEF in the HCC cases were higher than the types 2 and 3 hemangioma cases (P < .01). The 10th percentile HAC in the HCC cases was higher than the type 2 hemangioma cases (P < .05). The mean value, and the 10th and 50th percentile HAC in the HCC cases were higher than the type 3 hemangioma case (P < .05). However, there was no statistically significant difference in HAC between the HCC and type 1 hemangioma cases (P > .05).Quantitative measurement of perfusion parameters and heterogeneity analysis show significance differences in the early detection and differential diagnosis of HCC and hemangioma cases, which might contribute to increasing the diagnostic accuracy.
机译：本研究旨在探讨肝细胞癌（HCC）和血管瘤鉴别诊断中灌注参数的定量方法和异质性。本回顾性研究共纳入32例HCC和44例血管瘤（1、2和3型）。计算肝动脉系数（HAC），门静脉系数（PVC）和动脉增强分数（AEF）。分析了肿瘤异质性。比较肝癌和血管瘤（特别是非典型血管瘤）病例以及实质病变部位和周围正常组织之间的灌注参数和相应的百分位数，平均值分别为PVC的第10、50、75和90％肝癌病例明显低于1型和2型血管瘤病例（P he <.01）。此外，肝癌病例中第90个百分位数的PVC也显着低于3型血管瘤病例（P <.01），而肝癌病例中AEF的平均值和所有百分位数均高于2型和3型血管瘤病例（P <.01）。肝细胞癌病例中第10个百分点的HAC高于2型血管瘤病例（P <0.05）。肝癌病例的平均值以及第10和第50个百分点的HAC高于3型血管瘤病例（P <0.05）。但是，肝癌和1型血管瘤病例之间的HAC差异无统计学意义（P> .05）。灌注参数的定量测量和异质性分析显示，在HCC和血管瘤病例的早期检测和鉴别诊断中存在显着差异。可能有助于提高诊断准确性。

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