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Mechanical stimuli in the local in vivo environment in bone: Computational approaches linking organ-scale loads to cellular signals

机译：骨骼局部体内环境中的机械刺激：将器官规模负荷与细胞信号联系起来的计算方法

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Purpose of ReviewConnecting organ-scale loads to cellular signals in their local in vivo environment is a current challenge in the field of bone (re)modelling. Understanding this critical missing link would greatly improve our ability to anticipate mechanotransduction during different modes of stimuli, and the resultant cellular responses. This review characterises computational approaches that could enable coupling links across the multiple scales of bone.

机译：综述的目的在器官（局部）建模领域，将器官规模的负荷连接到其局部体内环境中的细胞信号是当前的挑战。理解这一关键的缺失环节将极大地提高我们预期在不同刺激模式下进行机械转导的能力，以及由此产生的细胞反应。这篇综述描述了可以实现跨越多个骨骼尺度的耦合链接的计算方法的特征。

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期刊名称 other
作者
Graeme R. Paul; Angad Malhotra; Ralph Müller;
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年(卷),期 -1(16),4
年度 -1
页码 395–403
总页数 16
原文格式 PDF
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关键词
Mechanical stimulation osteocytes computational systems biomechanics local in vivo environment bone (re)modelling;

机译：机械刺激;骨细胞;生物力学计算系统;体内局部环境;骨骼（重新）建模;

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专利

1. The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling [J] . An M. Nguyen, Y.-N. Young, Christopher R. Jacobs Biology Open . 2015,第12期

机译：初级纤毛是对机械刺激和细胞信号传导的自我适应，整合的联系。初级纤毛是对机械刺激和细胞信号传导的自我适应，整合的联系。初级纤毛是对机械刺激和细胞的自我适应的，整合的联系发信号
2. Analysis of avian bone response to mechanical loading, Part Two: Development of a computational connected cellular network to study bone intercellular communication [J] . Li Y. Mi, Mitra Basu, Susannah P. Fritton, Biomechanics and modeling in mechanobiology . 2005,第2a3期

机译：禽骨对机械负荷的反应分析，第二部分：开发计算连接的蜂窝网络以研究骨细胞间的通讯
3. High throughput computational evaluation of how scaffold architecture, material selection, and loading modality influence the cellular micromechanical environment in tissue engineering strategies [J] . Mitchell I. Page, Peter E. Linde, Christian M. Puttlitz JOR spine. . 2021,第3期

机译：高吞吐量计算评估脚手架架构如何，材料选择和装载模态如何影响组织工程策略中的蜂窝微机械环境
4. Dynamic Acoustic Force as a Mechanobioological Signal in Cellular Adaptation and In Vivo Bone Regenaration [C] . Yi-Xian Qin, Shu Zhang, Suzanne Ferreri, World biomaterials congress . 2012

机译：动态声力作为细胞适应和体内骨再生中的机械生物学信号。
5. Spatial localization of mechanical stimuli and cellular responses during bone healing in vivo. [D] . Leong, Pui Leng. 2011

机译：体内骨愈合过程中机械刺激和细胞反应的空间定位。
6. Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading [O] . Jason A. Bleedorn, Troy A. Hornberger, Craig A. Goodman, 2012

机译：体内骨负荷后骨骼和背根神经节神经元的时间性机械诱导信号事件
7. Mechanical Stimuli in the Local In Vivo Environment in Bone: Computational Approaches Linking Organ-Scale Loads to Cellular Signals [O] . Graeme R. Paul, Angad Malhotra, Ralph Müller 2018

机译：骨骼中局部体内环境中的机械刺激：将器官尺度载荷连接到蜂窝信号的计算方法

Mechanical stimuli in the local in vivo environment in bone: Computational approaches linking organ-scale loads to cellular signals

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